ZFIN ID: ZDB-GENE-040121-1
Gene Name: mitogen-activated protein kinase 3
Gene Symbol: mapk3    Nomenclature History

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Previous Names: ERK1 (1), fi06b09 (1), wu:fi06b09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have MAP kinase activity. Involved in central nervous system development; chordate embryonic development; and eye development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Is expressed in several structures, including EVL; brain; cranium; digestive system; and heart. Orthologous to human MAPK3 (mitogen-activated protein kinase 3).
Genome Resources: Alliance (1),  Gene:399480 (1),  Ensembl(GRCz11):ENSDARG00000070573 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13198 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20017 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mapk3
    1
    MO1-mapk3 N/A 1
    MO2-mapk3 N/A 1
    MO3-mapk3 N/A 2
    MO4-mapk3 N/A 2
    MO5-mapk3 N/A 2
    MO6-mapk3 N/A 1
    DISEASE ASSOCIATED WITH mapk3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mapk3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mapk3-201 (1)    Ensembl 2122
    ncRNA mapk3-002 (1)    Ensembl 711
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-mapk monoclonal IgG1 Mouse IHC, WB Sigma-Aldrich
    19
    Ab3-mapk polyclonal IgG Rabbit WB Santa Cruz Biotechnology, Inc.
    8
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mapk3 No data available
    MARKER RELATIONSHIPS
    mapk3 Contained in: [BAC] CH73-33I10 (1)
    mapk3 Encodes: [EST] eu231 (1), fi06b09
    [cDNA] MGC:55955 (1), MGC:77403 (1), MGC:114000 (1), MGC:191135 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201507 (1) 2078 nt
    Genomic GenBank:FP016144 (1) 105292 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZVK8 (1) 392 aa
    Sequence Information (all 27)
    ORTHOLOGY for mapk3 ( Chr: 3 )
    CITATIONS (61)