Gene

mapk3

ID
ZDB-GENE-040121-1
Name
mitogen-activated protein kinase 3
Symbol
mapk3 Nomenclature History
Previous Names
  • ERK1 (1)
  • fi06b09 (1)
  • wu:fi06b09 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have MAP kinase activity. Involved in central nervous system development; chordate embryonic development; and eye development. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cranium; digestive system; and heart. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 11 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mapk3 Human Ortholog
No data available
Associated With mapk3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
Domain IPR000719 Protein kinase domain
Family IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Mitogen-activated protein (MAP) kinase, conserved site Mitogen-activated protein (MAP) kinase, ERK1/2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q7ZVK8 392
UniProtKB:Q9DGR6 391
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-mapk monoclonal IgG1 Mouse
  • IHC
  • WB
Sigma-Aldrich
20
Ab3-mapk polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
8
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations