Gene

sparc

ID

ZDB-GENE-030131-9

Name

secreted protein, acidic, cysteine-rich (osteonectin)

Symbol

sparc Nomenclature History

Previous Names

hm:zeh0062
osn (1)
osteonectin (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Orthologous to human SPARC (secreted protein acidic and cysteine rich).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 22 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6910025 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sparc Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
osteogenesis imperfecta type 17	Alliance	Osteogenesis imperfecta, type XVII	616507

Associated With sparc Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Conserved_site	IPR001999	Osteonectin-like, conserved site
Domain	IPR002350	Kazal domain
Domain	IPR003645	Follistatin-like, N-terminal
Domain	IPR015369	Follistatin/Osteonectin EGF domain
Domain	IPR019577	SPARC/Testican, calcium-binding domain
Domain	IPR037641	SPARC, follistatin-like domain
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR036058	Kazal domain superfamily

Domain Details Per Protein

Protein	Length	EF-Hand 1, calcium-binding site	EF-hand domain pair	Follistatin-like, N-terminal	Follistatin/Osteonectin EGF domain	Kazal domain	Kazal domain superfamily	Osteonectin-like, conserved site	SPARC, follistatin-like domain	SPARC/Testican, calcium-binding domain
UniProtKB:Q6IQH0 InterPro	291

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sparc-201 (1) Ensembl	Ensembl	1,724 nt	Select Tool
mRNA	sparc-202 (1) Ensembl	Ensembl	865 nt	Select Tool
mRNA	sparc-203 (1) Ensembl	Ensembl	544 nt	Select Tool
mRNA	sparc-206 (1) Ensembl	Ensembl	520 nt	Select Tool
mRNA	sparc-207 (1) Ensembl	Ensembl	2,567 nt	Select Tool ZFIN BLAST
ncRNA	sparc-005 (1) Ensembl	Ensembl	836 nt	Select Tool
ncRNA	sparc-006 (1) Ensembl	Ensembl	726 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-sparc	polyclonal	sparc		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations