ZFIN ID: ZDB-GENE-030131-9
Gene Name: secreted protein, acidic, cysteine-rich (osteonectin)
Gene Symbol: sparc    Nomenclature History

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Previous Names: hm:zeh0062, osn (1), osteonectin (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to localize to extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich).
Genome Resources: Alliance (1),  Gene:321357 (1),  Ensembl(GRCz11):ENSDARG00000019353 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018906Tg Transgenic Insertion Unknown Unknown DNA
la027518Tg Transgenic Insertion Unknown Unknown DNA
sa22480 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22481 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sparc N/A 2
    MO2-sparc N/A 2
    MO3-sparc N/A 2
    MO4-sparc N/A 1
    DISEASE ASSOCIATED WITH sparc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    osteogenesis imperfecta type 17 Alliance Osteogenesis imperfecta, type XVII 616507
    DISEASE ASSOCIATED WITH sparc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process erythrocyte differentiation (more)
    Cellular Component extracellular space (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sparc-201 (1)    Ensembl 1724
    sparc-202 (1)    Ensembl 865
    sparc-203 (1)    Ensembl 544
    sparc-206 (1)    Ensembl 520
    ncRNA sparc-005 (1)    Ensembl 836
    sparc-006 (1)    Ensembl 726
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-sparc polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sparc No data available
    MARKER RELATIONSHIPS
    sparc Contained in: [BAC] DKEY-97O1 (1) (order this)
    sparc Contains: [SNP] rs3727771, rs3727772, rs3727773, rs3727774
    sparc Encodes: [EST] IMAGE:6910025 (1), zeh0062
    [cDNA] MGC:86767 (1)
    sparc Has Artifact: [EST] fa96a08 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001942 (1) 1688 nt
    Genomic GenBank:BX640507 (1) 189019 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JPZ8 (1) 291 aa
    Sequence Information (all 21)
    ORTHOLOGY for sparc ( Chr: 14 )
    CITATIONS (69)