Gene

sparc

ID
ZDB-GENE-030131-9
Name
secreted protein, acidic, cysteine-rich (osteonectin)
Symbol
sparc Nomenclature History
Previous Names
  • hm:zeh0062
  • osn (1)
  • osteonectin (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to localize to extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich).
Genome Resources
Note
None
Expression
All Expression Data
27 figures from 14 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sparc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
osteogenesis imperfecta type 17 Alliance Osteogenesis imperfecta, type XVII 616507
Associated With sparc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Conserved_site IPR001999 Osteonectin-like, conserved site
Domain IPR002350 Kazal domain
Domain IPR003645 Follistatin-like, N-terminal
Domain IPR015369 Follistatin/Osteonectin EGF domain
Domain IPR019577 SPARC/Testican, calcium-binding domain
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR036058 Kazal domain superfamily
Domain Details Per Protein
Protein Length EF-Hand 1, calcium-binding site EF-hand domain pair Follistatin-like, N-terminal Follistatin/Osteonectin EGF domain Kazal domain Kazal domain superfamily Osteonectin-like, conserved site SPARC/Testican, calcium-binding domain
UniProtKB:E9QJC0 109
UniProtKB:E9QJA9 237
UniProtKB:Q6PVV8 291
UniProtKB:E9QCC2 157
UniProtKB:Q6IQH0 291
UniProtKB:A0A0B5JPZ8 291
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-sparc polyclonal Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations