ZFIN

ZFIN ID: ZDB-GENE-011205-7

ZFIN ID: ZDB-GENE-011205-7

CITATIONS (74 total)

Gene Name:	NADH dehydrogenase 1, mitochondrial
Gene Symbol:	mt-nd1

Bhandari, S., Kim, Y.I., Nam, I.K., Hong, K., Jo, Y., Yoo, K.W., Liao, W., Lim, J.Y., Kim, S.J., Um, J.Y., Kim, P.K., Lee, H.S., Ryu, D., Kim, S.H., Kwak, S., Park, R., Choe, S.K. (2023) Loss of pex5 sensitizes zebrafish to fasting due to deregulated mitochondria, mTOR, and autophagy. Cellular and molecular life sciences : CMLS. 80:6969

Van Haute, L., O'Connor, E., Díaz-Maldonado, H., Munro, B., Polavarapu, K., Hock, D.H., Arunachal, G., Athanasiou-Fragkouli, A., Bardhan, M., Barth, M., Bonneau, D., Brunetti-Pierri, N., Cappuccio, G., Caruana, N.J., Dominik, N., Goel, H., Helman, G., Houlden, H., Lenaers, G., Mention, K., Murphy, D., Nandeesh, B., Olimpio, C., Powell, C.A., Preethish-Kumar, V., Procaccio, V., Rius, R., Rebelo-Guiomar, P., Simons, C., Vengalil, S., Zaki, M.S., Ziegler, A., Thorburn, D.R., Stroud, D.A., Maroofian, R., Christodoulou, J., Gustafsson, C., Nalini, A., Lochmüller, H., Minczuk, M., Horvath, R. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nature communications. 14:10091009

Lv, X., Zhang, R., Xu, L., Wang, G., Yan, C., Lin, P. (2022) Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes. Frontiers in cell and developmental biology. 10:836464

Sabharwal, A., Wishman, M.D., Cervera, R.L., Serres, M.R., Anderson, J.L., Holmberg, S.R., Kar, B., Treichel, A.J., Ichino, N., Liu, W., Yang, J., Ding, Y., Deng, Y., Lacey, J.M., Laxen, W.J., Loken, P.R., Oglesbee, D., Farber, S.A., Clark, K.J., Xu, X., Ekker, S.C. (2022) Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. eLIFE. 11:

Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888

Tian, J., Du, Y., Yu, E., Lei, C., Xia, Y., Jiang, P., Li, H., Zhang, K., Li, Z., Gong, W., Xie, J., Wang, G. (2022) Prostaglandin 2α Promotes Autophagy and Mitochondrial Energy Production in Fish Hepatocytes. Cells. 11(12)

Castillo-Castellanos, F., Ramírez, L., Lomelí, H. (2021) zmiz1a zebrafish mutants have defective erythropoiesis, altered expression of autophagy genes, and a deficient response to vitamin D. Life sciences. 284:119900

Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33

Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100

Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988

Lee, J.Y., Park, H., Lim, W., Song, G. (2021) Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. The Science of the total environment. 771:145445

Li, X.Y., Qin, Y.J., Wang, Y., Huang, T., Zhao, Y.H., Wang, X.H., Martyniuk, C.J., Yan, B. (2021) Relative comparison of strobilurin fungicides at environmental levels: Focus on mitochondrial function and larval activity in early staged zebrafish (Danio rerio). Toxicology. 452:152706

Minenkova, A., Jansen, E.E.W., Cameron, J., Barto, R., Hurd, T., MacNeil, L., Salomons, G.S., Mercimek-Andrews, S. (2021) Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?. PLoS One. 16:e0257073

Ogawa, M., Geng, F.S., Humphreys, D.T., Kristianto, E., Sheng, D.Z., Hui, S.P., Zhang, Y., Sugimoto, K., Nakayama, M., Zheng, D., Hesselson, D., Hodson, M.P., Bogdanovic, O., Kikuchi, K. (2021) Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Science (New York, N.Y.). 372:201-205

Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991

Ullah, F., Rauf, W., Khan, K., Khan, S., Bell, K.M., de Oliveira, V.C., Tariq, M., Bakhshalizadeh, S., Touraine, P., Katsanis, N., Sinclair, A., He, S., Tucker, E.J., Baig, S.M., Davis, E.E. (2021) A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss. Human genetics. 140(12):1733-1751

Zhang, Q., He, X., Yao, S., Lin, T., Zhang, L., Chen, D., Chen, C., Yang, Q., Li, F., Zhu, Y.M., Guan, M.X. (2021) Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Nucleic acids research. 49(8):4689-4704

Maharaj, S., El Ahmadie, N., Rheingold, S., El-Chehouri, J., Yang, L., Souders, C.L., Martyniuk, C.J. (2020) Sub-lethal toxicity assessment of the phenylurea herbicide linuron in developing zebrafish (Danio rerio) embryo/larvae. Neurotoxicology and teratology. 81:106917

Otten, A.B.C., Kamps, R., Lindsey, P., Gerards, M., Pendeville-Samain, H., Muller, M., van Tienen, F.H.J., Smeets, H.J.M. (2020) Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:381

Tseng, Y.T., Li, S.W., HuangFu, W.C., Yen, Y., Liu, I.H. (2020) The single nucleotide variant at c.662A>G in human RRM2B is a loss-of-function mutation. Molecular genetics & genomic medicine. 8(11):e1497

Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2020) Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Environmental pollution (Barking, Essex : 1987). 265:115031

Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307

Bian, W.P., Chen, Y., Luo, J., Wang, C., Xie, S., Pei, D. (2019) A knock-in strategy for editing human and zebrafish mitochondrial DNA using mito-CRISPR/Cas9 system. ACS synthetic biology. 8(4):621-632

Del Dotto, V., Ullah, F., Di Meo, I., Magini, P., Gusic, M., Maresca, A., Caporali, L., Palombo, F., Tagliavini, F., Baugh, E.H., Macao, B., Szilagyi, Z., Péron, C., Gustafson, M.A., Khan, K., La Morgia, C., Barboni, P., Carbonelli, M., Valentino, M.L., Liguori, R., Shashi, V., Sullivan, J.A., Nagaraj, S., El-Dairi, M., Iannaccone, A., Cutcutache, I., Bertini, E., Carrozzo, R., Emma, F., Diomedi-Camassei, F., Zanna, C., Armstrong, M., Page, M.J., Boesch, S., Wortmann, S.B., Kopajtich, R., Stong, N., Sperl, W., Davis, E., Copeland, W.C., Seri, M., Falkenberg, M., Prokisch, H., Katsanis, N., Tiranti, V., Pippucci, T., Carelli, V. (2019) SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder. The Journal of Clinical Investigation. 130(1):108-125

Park, K.H., Ye, Z.W., Zhang, J., Hammad, S.M., Townsend, D.M., Rockey, D.C., Kim, S.H. (2019) 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Scientific Reports. 9:1138

Park, K.H., Ye, Z.W., Zhang, J., Kim, S.H. (2019) Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish. Zebrafish. 16(6):497-504

Cao, F., Wu, P., Huang, L., Li, H., Qian, L., Pang, S., Qiu, L. (2018) Short-term developmental effects and potential mechanisms of azoxystrobin in larval and adult zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 198:129-140

Li, H., Yu, S., Cao, F., Wang, C., Zheng, M., Li, X., Qiu, L. (2018) Developmental toxicity and potential mechanisms of pyraoxystrobin to zebrafish (Danio rerio). Ecotoxicology and environmental safety. 151:1-9

Li, X., Zha, X., Wang, Y., Jia, R., Hu, B., Zhao, B. (2018) Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development. Chemosphere. 200:302-312

Munro, B., Horvath, R., Müller, J.S. (2018) Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok-/- zebrafish. Human molecular genetics. 28(5):796-803

Sabharwal, A., Sharma, D., Vellarikkal, S.K., Jayarajan, R., Verma, A., Senthivel, V., Scaria, V., Sivasubbu, S. (2018) Organellar transcriptome sequencing reveals mitochondrial localization of nuclear encoded transcripts. Mitochondrion. 46:59-68

Sokol, A.M., Uszczynska-Ratajczak, B., Collins, M.M., Bazala, M., Topf, U., Lundegaard, P.R., Sugunan, S., Guenther, S., Kuenne, C., Graumann, J., Chan, S.S.L., Stainier, D.Y.R., Chacinska, A. (2018) Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish. PLoS Genetics. 14:e1007743

Zhang, Q., Zhang, L., Chen, D., He, X., Yao, S., Zhang, Z., Chen, Y., Guan, M.X. (2018) Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function. Nucleic acids research. 46(20):10930-10945

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Chen, L., Hu, Y., He, J., Chen, J., Giesy, J.P., Xie, P. (2017) Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Environmental science & technology. 51(1):596-607

He, S., Wang, Q., Li, S., Ran, C., Guo, X., Zhang, Z., Zhou, Z. (2017) Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis. Science China. Life sciences. 60(11):1260-1270

Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z. (2017) Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)₂D₃.. Cell Reports. 19:1444-1455

Romney, A.L., Podrabsky, J.E. (2017) Transcriptomic analysis of maternally provisioned cues for phenotypic plasticity in the annual killifish, Austrofundulus limnaeus.. EvoDevo. 8:6

Wang, Y., Teng, M., Wang, D., Yan, J., Miao, J., Zhou, Z., Zhu, W. (2017) Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Environmental pollution (Barking, Essex : 1987). 229:264-271

Yang, Y., Liu, W., Li, D., Qian, L., Fu, B., Wang, C. (2017) Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 183:89-96

Flynn, T., Signal, B., Johnson, S.L., Gemmell, N.J. (2016) Mitochondrial genome diversity among six laboratory zebrafish (Danio rerio) strains. Mitochondrial DNA. 27(6):4364-4371

Otten, A.B., Stassen, A.P., Adriaens, M., Gerards, M., Dohmen, R.G., Timmer, A.J., Vanherle, S.J., Kamps, R., Boesten, I.B., Vanoevelen, J.M., Muller, M., Smeets, B. (2016) Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number. Genetics. 204(4):1423-1431

Otten, A.B., Theunissen, T.E., Derhaag, J.G., Lambrichs, E.H., Boesten, I.B., Winandy, M., van Montfoort, A.P., Tarbashevich, K., Raz, E., Gerards, M., Vanoevelen, J.M., van den Bosch, B.J., Muller, M., Smeets, H.J. (2016) Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells. Cell Reports. 16(3):622-30

Pinho, B.R., Reis, S.D., Guedes-Dias, P., Leitão-Rocha, A., Quintas, C., Valentão, P., Andrade, P.B., Santos, M.M., Oliveira, J.M. (2016) Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: therapeutic implications for Parkinson's disease. Pharmacological research. 103:328-39

Yang, Y., Liu, W., Mu, X., Qi, S., Fu, B., Wang, C. (2016) Biological response of zebrafish embryos after short-term exposure to thifluzamide. Scientific Reports. 6:38485

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Liu, H., Sheng, N., Zhang, W., Dai, J. (2015) Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos. Journal of environmental sciences (China). 32:26-34

Rahn, J.J., Bestman, J.E., Stackley, K.D., Chan, S.S. (2015) Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth. Nucleic acids research. 43(21):10338-52

de Paula, W.B., Agip, A.N., Missirlis, F., Ashworth, R., Vizcay-Barrena, G., Lucas, C.H., and Allen, J.F. (2013) Female and male gamete mitochondria are distinct and complementary in transcription, structure, and genome function. Genome biology and evolution. 5(10):1969-1977

Rahn, J.J., Stackley, K.D., and Chan, S.S. (2013) Opa1 is required for proper mitochondrial metabolism in early development. PLoS One. 8(3):e59218

Artuso, L., Romano, A., Verri, T., Domenichini, A., Argenton, F., Santorelli, F.M., and Petruzzella, V. (2012) Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio). Biochim. Biophys. Acta Bio-Energetics. 1817(7):1002-1011

Catalina-Rodriguez, O., Kolukula, V.K., Tomita, Y., Preet, A., Palmieri, F., Wellstein, A., Byers, S., Giaccia, A.J., Glasgow, E., Albanese, C., and Avantaggiati, M.L. (2012) The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget. 3(10):1220-1235

Hugo, S.E., Cruz-Garcia, L., Karanth, S., Anderson, R.M., Stainier, D.Y., and Schlegel, A. (2012) A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes & Development. 26(3):282-93

Jin, Y., Zheng, S., Pu, Y., Shu, L., Sun, L., Liu, W., and Fu, Z. (2011) Cypermethrin has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish (Danio rerio). Chemosphere. 82(3):398-404

Jin, Y., Zhang, X., Shu, L., Chen, L., Sun, L., Qian, H., Liu, W., and Fu, Z. (2010) Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere. 78(7):846-852

Liu, Y., Wang, J., Wei, Y., Zhang, H., Xu, M., and Dai, J. (2008) Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquatic toxicology (Amsterdam, Netherlands). 89(4):242-250

Broughton, R.E., Milam, J.E., and Roe, B.A. (2001) The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA. Genome research. 11(11):1958-1967

Additional Citations (17):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Manual Curation of UniProt IDs. Manually curated data.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.