ZFIN

ZFIN ID: ZDB-GENE-000125-12

ZFIN ID: ZDB-GENE-000125-12

CITATIONS (60 total)

Gene Name:	insulin-like growth factor binding protein 2a
Gene Symbol:	igfbp2a

D'Gama, P.P., Qiu, T., Cosacak, M.I., Rayamajhi, D., Konac, A., Hansen, J.N., Ringers, C., Acuña-Hinrichsen, F., Hui, S.P., Olstad, E.W., Chong, Y.L., Lim, C.K.A., Gupta, A., Ng, C.P., Nilges, B.S., Kashikar, N.D., Wachten, D., Liebl, D., Kikuchi, K., Kizil, C., Yaksi, E., Roy, S., Jurisch-Yaksi, N. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell Reports. 37:109775

Kamei, H., Duan, C. (2021) Alteration of organ size and allometric scaling by organ-specific targeting of IGF signaling. General and comparative endocrinology. 314:113922

Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831

Liu, C., Li, S., Noer, P.R., Kjaer-Sorensen, K., Juhl, A.K., Goldstein, A., Ke, C., Oxvig, C., Duan, C. (2020) The metalloproteinase Papp-aa controls epithelial cell quiescence-proliferation transition. eLIFE. 9:

Wang, L., Yan, R., Yang, Q., Li, H., Zhang, J., Shimoda, Y., Kato, K., Yamanaka, K., An, Y. (2020) Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos. Ecotoxicology and environmental safety. 201:110820

Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307

Huang, V., Butler, A.A., Lubin, F.D. (2019) Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Scientific Reports. 9:1379

Li, J., Wang, Y., Kang, T., Li, X., Niu, C. (2019) Insulin-like growth factor binding proteins inhibit oocyte maturation of zebrafish. General and comparative endocrinology. 281:83-90

Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150

Boskovic, S., Marín-Juez, R., Jasnic, J., Reischauer, S., El Sammak, H., Kojic, A., Faulkner, G., Radojkovic, D., Stainier, D.Y.R., Kojic, S. (2018) Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PLoS One. 13:e0204312

Dang, Y., Wang, F., Liu, C. (2018) Real-time PCR array to study the effects of chemicals on the growth hormone/insulin-like growth factors (GH/IGFs) axis of zebrafish embryos/larvae. Chemosphere. 207:365-376

Kim, O.T.P., Nguyen, P.T., Shoguchi, E., Hisata, K., Vo, T.T.B., Inoue, J., Shinzato, C., Le, B.T.N., Nishitsuji, K., Kanda, M., Nguyen, V.H., Nong, H.V., Satoh, N. (2018) A draft genome of the striped catfish, Pangasianodon hypophthalmus, for comparative analysis of genes relevant to development and a resource for aquaculture improvement. BMC Genomics. 19:733

Pasquier, J., Braasch, I., Batzel, P., Cabau, C., Montfort, J., Nguyen, T., Jouanno, E., Berthelot, C., Klopp, C., Journot, L., Postlethwait, J.H., Guiguen, Y., Bobe, J. (2017) Evolution of gene expression after whole-genome duplication: New insights from the spotted gar genome. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):709-721

Safian, D., van der Kant, H.J.G., Crespo, D., Bogerd, J., Schulz, R.W. (2017) Follicle-Stimulating Hormone Regulates igfbp Gene Expression Directly or via Downstream Effectors to Modulate Igf3 Effects on Zebrafish Spermatogenesis.. Frontiers in endocrinology. 8:328

Tian, J., Wang, K., Wang, X., Wen, H., Zhou, H., Liu, C., Mai, K., He, G. (2017) Soybean Saponin Modulates Nutrient Sensing Pathways and Metabolism in Zebrafish. General and comparative endocrinology. 257:246-254

Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Lu, J., Liu, K.C., Schulz, N., Karampelias, C., Charbord, J., Hilding, A., Rautio, L., Bertolino, P., Östenson, C.G., Brismar, K., Andersson, O. (2016) IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation. The EMBO journal. 35(18):2026-44

Safian, D., Morais, R.D., Bogerd, J., Schulz, R.W. (2016) Igf binding proteins protect undifferentiated spermatogonia in the zebrafish testis against excessive differentiation. Endocrinology. 157(11):4423-4433

Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F.N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., PROMESA investigators, Le Tourneau, T., Chen, M.H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M., Hercberg, S., Roussel, R., Benjamin, E.J., Bonnet, F., Lo, S.H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R., Le Marec, H., Froguel, P., Ellinor, P.T., Vasan, R.S., Bruneval, P., Markwald, R.R., Norris, R.A., Milan, D.J., Slaugenhaupt, S.A., Levine, R.A., Schott, J.J., Hagege, A.A., Mvp-France, Jeunemaitre, X., Leducq Transatlantic MITRAL Network (2015) Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nature Genetics. 47(10):1206-11

Arslan-Ergul, A., and Adams, M.M. (2014) Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. BMC Neuroscience. 15:29

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Kessels, M.Y., Huitema, L.F., Boeren, S., Kranenbarg, S., Schulte-Merker, S., van Leeuwen, J.L., de Vries, S.C. (2014) Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One. 9:e90568

Amaral, I.P., and Johnston, I.A. (2011) Insulin-like growth factor (IGF) signalling and genome-wide transcriptional regulation in fast muscle of zebrafish following a single-satiating meal. The Journal of experimental biology. 214(13):2125-2139

Daza, D.O., Sundström, G., Bergqvist, C.A., Duan, C., and Larhammar, D. (2011) Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology. 152(6):2278-2289

Nachtrab, G., Czerwinski, M., and Poss, K.D. (2011) Sexually Dimorphic Fin Regeneration in Zebrafish Controlled by Androgen/GSK3 Signaling. Current biology : CB. 21(22):1912-7

Dai, W., Kamei, H., Zhao, Y., Ding, J., Du, Z., and Duan, C. (2010) Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(6):2020-2029

Hegde, A., Qiu, N.C., Qiu, X., Ho, S.H., Tay, K.Q., George, J., Ng, F.S., Govindarajan, K.R., Gong, Z., Mathavan, S., and Jiang, Y.J. (2008) Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes. PLoS One. 3(1):e1479

Rodgers, B.D., Roalson, E.H., and Thompson, C. (2008) Phylogenetic analysis of the insulin-like growth factor binding protein (IGFBP) and IGFBP-related protein gene families. General and comparative endocrinology. 155(1):201-207

Sundstrom, G., Larsson, T.A., and Larhammar, D. (2008) Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evolutionary Biology. 8(1):254

Zhou, J., Li, W., Kamei, H., and Duan, C. (2008) Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS One. 3(12):e3926

Cheng, W., Guo, L., Zhang, Z., Soo, H.M., Wen, C., Wu, W., and Peng, J. (2006) HNF factors form a network to regulate liver-enriched genes in zebrafish. Developmental Biology. 294(2):482-496

Hoffmann, J.L., Torontali, S.P., Thomason, R.G., Lee, D.M., Brill, J.L., Price, B.B., Carr, G.J., Versteeg, D.J. (2006) Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Aquatic toxicology (Amsterdam, Netherlands). 79(3):233-246

Chen, J.Y., Chou, M.J., Gong, H.Y., Huang, T.C., Wu, J.L., and Kuo, C.M. (2005) Cloning and Biological Analysis of the Zebrafish (Danio rerio) Insulin-Like Growth Factor Binding Protein-2 Proximal Promoter Region. DNA and cell biology. 24(3):199-208

Kajimura, S., Aida, K., and Duan, C. (2005) Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proceedings of the National Academy of Sciences of the United States of America. 102(4):1240-1245

Li, Y., Xiang, J., and Duan, C. (2005) Insulin-like Growth Factor-binding Protein-3 Plays an Important Role in Regulating Pharyngeal Skeleton and Inner Ear Formation and Differentiation. The Journal of biological chemistry. 280(5):3613-3620

Wood, A.W., Duan, C., and Bern, H.A. (2005) Insulin-Like Growth Factor Signaling in Fish. International review of cytology. 243:215-285

Wood, A.W., Schlueter, P.J., and Duan, C. (2005) Targeted knockdown of insulin-like growth factor binding protein-2 (IGFBP-2) disrupts cardiovascular development in zebrafish embryos. Molecular endocrinology (Baltimore, Md.). 19(4):1024-1034

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Duan, C., Ding, J., Schlueter, P.J., Li, Y., Zhang J., and Royer, T. (2003) A zebrafish view of the insulin-like growth factor signaling pathway. Dong wu xue bao. [Acta zoologica Sinica]. 49:421-431

Duan, C. (2002) Regulation of insulin-like growth factor (IGF) actions by IGF binding protein in zebrafish. Fisheries science : FS. 68:765-768

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Duan, C.M., Ding, J., Li, Q., Tsai, W., and Pozios, K. (1999) Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 96(26):15274-15279

Additional Citations (17):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2020) Nomenclature Data Curation (2020). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.