ZFIN ID: ZDB-PUB-190107-1
The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling
Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X.
Date: 2019
Source: Developmental Biology   446(2): 142-150 (Journal)
Registered Authors: Li, Beibei, Lou, Xin, Yang, Yuxi
Keywords: Neuregulin-ERBB signalling, heart development, ventricle trabeculation, zebrafish, zfpm1
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Cell Proliferation/genetics
  • Cells, Cultured
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Gene Knockout Techniques
  • Heart/embryology
  • Microscopy, Confocal
  • Myocardium/cytology
  • Myocardium/metabolism*
  • Myocytes, Cardiac/cytology
  • Myocytes, Cardiac/metabolism
  • Neuregulins/genetics*
  • Neuregulins/metabolism
  • Receptor, ErbB-2/genetics*
  • Receptor, ErbB-2/metabolism
  • Signal Transduction/genetics*
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism
PubMed: 30611731 Full text @ Dev. Biol.
Ventricular trabeculation is one essential step for generating a functionally competent ventricular wall, while how the early trabeculae carneae forms and subsequently develops into mature chambers is poorly understood. We found that in zebrafish zfpm1-/- juvenile, cardiac function is significantly compromised, with hearts exhibiting deformed trabecular meshwork. To elucidate the mechanisms of Zfpm1 function in cardiac trabeculation, we analyzed zfpm1 mutant hearts more closely and found that loss of Zfpm1 activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation during cardiac trabeculae growth and modeling stages. These results implicate Zfpm1 plays a pivotal role in coordinating trabeculae patterning and growth.