ZFIN ID: ZDB-PERS-970908-23
Tsang, Michael
Email: tsang@pitt.edu
Affiliation: Tsang Lab
Address: Department of Microbiology & Molecular Genetics University of Pittsburgh School of Medicine 3501 Fifth Avenue BST3-5062 Pittsburgh, PA 15213 USA
Country: United States
Phone: (412) 648-3248
Fax: (412) 383 5918


Brown, W., Bardhan, A., Darrah, K., Tsang, M., Deiters, A. (2022) Optical Control of MicroRNA Function in Zebrafish Embryos. Journal of the American Chemical Society. 144(37):16819-16826
Darrah, K., Wesalo, J., Lukasak, B., Tsang, M., Chen, J.K., Deiters, A. (2021) Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. Journal of the American Chemical Society. 143(44):18665-18671
Courtney, T.M., Darrah, K.E., Horst, T.J., Tsang, M., Deiters, A. (2021) Blue Light Activated Rapamycin for Optical Control of Protein Dimerization in Cells and Zebrafish Embryos. ACS Chemical Biology. 16(11):2434-2443
Missinato, M.A., Zuppo, D.A., Watkins, S.C., Bruchez, M.P., Tsang, M. (2021) Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(7):986-1000
Zhou, W., Brown, W., Bardhan, A., Delaney, M., Ilk, A., Rauen, R., Kahn, S., Tsang, M., Deiters, A. (2020) Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light-Activated Guide RNA. Angewandte Chemie (International ed. in English). 59(23):8998-9003
Rochon, E., Missinato, M.A., Xue, J., Tejero, J., Tsang, M., Gladwin, M.T., Corti, P. (2019) Nitrite improves heart regeneration in zebrafish. Antioxidants & redox signaling. 32(6):363-377
Skvarca, L.B., Han, H.I., Espiritu, E.B., Missinato, M.A., Rochon, E.R., McDaniels, M.D., Bais, A.S., Roman, B.L., Waxman, J.S., Watkins, S.C., Davidson, A.J., Tsang, M., Hukriede, N.A. (2019) Enhancing acute kidney injury regeneration by promoting cellular dedifferentiation in zebrafish. Disease models & mechanisms. 12(4):
Saydmohammed, M., Yagi, H., Calderon, M., Clark, M.J., Feinstein, T., Sun, M., Stolz, D.B., Watkins, S.C., Amack, J.D., Lo, C.W., Tsang, M. (2018) Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nature communications. 9:3381
Saydmohammed, M., Vollmer, L.L., Onuoha, E.O., Maskrey, T.S., Gibson, G., Watkins, S.C., Wipf, P., Vogt, A., Tsang, M. (2018) A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules. 23(7)
Brown, W., Liu, J., Tsang, M., Deiters, A. (2018) Cell Lineage Tracing in Zebrafish Embryos with an Expanded Genetic Code. Chembiochem : a European journal of chemical biology. 19(12):1244-1249
Kim, S.M., Long, D.W., Tsang, M.W.K., Wang, Y. (2018) Zebrafish extracellular matrix improves neuronal viability and network formation in a 3-dimensional culture. Biomaterials. 170:137-146
Missinato, M.A., Saydmohammed, M., Zuppo, D.A., Rao, K.S., Opie, G.W., Kühn, B., Tsang, M. (2018) Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development (Cambridge, England). 145(5)
Saydmohammed, M., Tsang, M. (2018) High-Throughput Automated Chemical Screens in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1683:383-393
Küchler, E.C., Silva, L.A.D., Nelson-Filho, P., Sabóia, T.M., Rentschler, A.M., Granjeiro, J.M., Oliveira, D., Tannure, P.N., Silva, R.A.D., Antunes, L.S., Tsang, M., Vieira, A.R. (2018) Assessing the association between hypoxia during craniofacial development and oral clefts. Journal of applied oral science : revista FOB. 26:e20170234
Liu, J., Hemphill, J., Samanta, S., Tsang, M., Deiters, A. (2017) Genetic Code Expansion in Zebrafish Embryos and Its Application to Optical Control of Cell Signaling. Journal of the American Chemical Society. 139(27):9100-9103
Liu, X., Yagi, H., Saeed, S., Bais, A.S., Gabriel, G.C., Chen, Z., Peterson, K.A., Li, Y., Schwartz, M.C., Reynolds, W.T., Saydmohammed, M., Gibbs, B., Wu, Y., Devine, W., Chatterjee, B., Klena, N.T., Kostka, D., de Mesy Bentley, K.L., Ganapathiraju, M.K., Dexheimer, P., Leatherbury, L., Khalifa, O., Bhagat, A., Zahid, M., Pu, W., Watkins, S., Grossfeld, P., Murray, S.A., Porter, G.A., Tsang, M., Martin, L.J., Woodrow Benson, D., Aronow, B.J., Lo, C.W. (2017) The complex genetics of hypoplastic left heart syndrome. Nature Genetics. 49(7):1152-1159
Kaltenmeier, C.T., Vollmer, L.L., Vernetti, L.A., Caprio, L., Davis, K., Korotchenko, V.N., Day, B.W., Tsang, M., Hulkower, K.I., Lotze, M.T., Vogt, A. (2017) A tumor cell-selective inhibitor of mitogen-activated protein kinase phosphatases sensitizes breast cancer cells to lymphokine-activated killer cell activity. The Journal of pharmacology and experimental therapeutics. 361(1):39-50
Corti, P., Xue, J., Tejero, J., Wajih, N., Sun, M., Stolz, D.B., Tsang, M., Kim-Shapiro, D.B., Gladwin, M.T. (2016) Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proceedings of the National Academy of Sciences of the United States of America. 113:8538-43
Treat, A.C., Wheeler, D.S., Stolz, D.B., Tsang, M., Friedman, P.A., Romero, G. (2016) The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization. PLoS One. 11(4):e0153144
He, J., Wang, Y., Missinato, M.A., Onuoha, E., Perkins, L.A., Watkins, S.C., St Croix, C.M., Tsang, M., Bruchez, M.P. (2016) A genetically targetable near-infrared photosensitizer. Nature Methods. 13(3):263-8
Li, Y., Yagi, H., Onuoha, E.O., Damerla, R.R., Francis, R., Furutani, Y., Tariq, M., King, S.M., Hendricks, G., Cui, C., Saydmohammed, M., Lee, D.M., Zahid, M., Sami, I., Leatherbury, L., Pazour, G.J., Ware, S.M., Nakanishi, T., Goldmuntz, E., Tsang, M., Lo, C.W. (2016) DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genetics. 12:e1005821
Guimier, A., Gabriel, G.C., Bajolle, F., Tsang, M., Liu, H., Noll, A., Schwartz, M., El Malti, R., Smith, L.D., Klena, N.T., Jimenez, G., Miller, N.A., Oufadem, M., Moreau de Bellaing, A., Yagi, H., Saunders, C.J., Baker, C.N., Di Filippo, S., Peterson, K.A., Thiffault, I., Bole-Feysot, C., Cooley, L.D., Farrow, E.G., Masson, C., Schoen, P., Deleuze, J.F., Nitschké, P., Lyonnet, S., de Pontual, L., Murray, S.A., Bonnet, D., Kingsmore, S.F., Amiel, J., Bouvagnet, P., Lo, C.W., Gordon, C.T. (2015) MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates. Nature Genetics. 47(11):1260-3
Missinato, M.A., Tobita, K., Romano, N., Carroll, J.A., Tsang, M. (2015) Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovascular research. 107(4):487-98
Wei, L., Nakajima, S., Böhm, S., Bernstein, K.A., Shen, Z., Tsang, M., Levine, A.S., Lan, L. (2015) DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 112(27):E3495-504
Hemphill, J., Liu, Q., Uprety, R., Samanta, S., Tsang, M., Juliano, R.L., Deiters, A. (2015) Conditional control of alternative splicing through light-triggered splice-switching oligonucleotides. Journal of the American Chemical Society. 137:3656-62
Korotchenko, V.N., Saydmohammed, M., Vollmer, L.L., Bakan, A., Sheetz, K., Debiec, K.T., Greene, K.A., Agliori, C.S., Bahar, I., Day, B.W., Vogt, A., Tsang, M. (2014) In Vivo Structure-Activity Relationship Studies Support Allosteric Targeting of a Dual Specificity Phosphatase. Chembiochem : a European journal of chemical biology. 15(10):1436-45
Umasankar, P.K., Sanker, S., Thieman, J.R., Chakraborty, S., Wendland, B., Tsang, M., and Traub, L.M. (2012) Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nature cell biology. 14(5):488-501
Willaert, A., Khatri, S., Callewaert, B.L., Coucke, P.J., Crosby, S.D., Lee, J.G., Davis, E.C., Shiva, S., Tsang, M., De Paepe, A., and Urban, Z. (2012) GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFβ signaling. Human molecular genetics. 21(6):1248-1259
Watkins, S.C., Maniar, S., Mosher, M., Roman, B.L., Tsang, M., and St Croix, C.M. (2012) High resolution imaging of vascular function in zebrafish. PLoS One. 7(8):e44018
Saydmohammed, M., Vollmer, L.L., Onuoha, E.O., Vogt, A., and Tsang, M. (2011) A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling. Birth defects research. Part C, Embryo today : reviews. 93(3):281-287
Dente, L., Gestri, G., Tsang, M., Kudoh, T., Wilson, S.W., Dawid, I.B., and Andreazzoli, M. (2011) Cloning and developmental expression of zebrafish pdzrn3. The International journal of developmental biology. 55(10-12):989-993
Wang, G., Cadwallader, A.B., Jang, D.S., Tsang, M., Yost, H.J., and Amack, J.D. (2011) The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish. Development (Cambridge, England). 138(1):45-54
Tsang, M. (2010) Zebrafish: A tool for chemical screens. Birth defects research. Part C, Embryo today : reviews. 90(3):185-192
Vogt, A., Codore, H., Day, B.W., Hukriede, N.A., and Tsang, M. (2010) Development of automated imaging and analysis for zebrafish chemical screens. Journal of visualized experiments : JoVE. (40)
Znosko, W.A., Yu, S., Thomas, K., Molina, G.A., Li, C., Tsang, W., Dawid, I.B., Moon, A.M., and Tsang, M. (2010) Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development. Developmental Biology. 342(1):11-25
Edeling, M.A., Sanker, S., Shima, T., Umasankar, P.K., Höning, S., Kim, H.Y., Davidson, L.A., Watkins, S.C., Tsang, M., Owen, D.J., and Traub, L.M. (2009) Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One. 4(12):e8150
Vogt, A., McPherson, P.A., Shen, X., Balachandran, R., Zhu, G., Raccor, B.S., Nelson, S.G., Tsang, M., and Day, B.W. (2009) High-Content Analysis of Cancer-Cell-Specific Apoptosis and Inhibition of in Vivo Angiogenesis by Synthetic (-)-Pironetin and Analogs. Chemical Biology & Drug Design. 74(4):358-368
Molina, G., Vogt, A., Bakan, A., Dai, W., de Oliveira, P.Q., Znosko, W., Smithgall, T.E., Bahar, I., Lazo, J.S., Day, B.W., and Tsang, M. (2009) Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nature Chemical Biology. 5(9):680-687
Shima, T., Znosko, W., and Tsang, M. (2009) The characterization of a zebrafish mid-hindbrain mutant, mid-hindbrain gone (mgo). Developmental Dynamics : an official publication of the American Association of Anatomists. 238(4):899-907
Hong, S.K., Tsang, M., and Dawid, I.B. (2008) The Mych Gene Is Required for Neural Crest Survival during Zebrafish Development. PLoS One. 3(4):e2029
Molina, G.A., Watkins, S.C., and Tsang, M. (2007) Generation of FGF reporter transgenic zebrafish and their utility in chemical screens. BMC Developmental Biology. 7(1):62
Tsang, M., Maegawa, S., Kiang, A., Habas, R., Weinberg, E., and Dawid, I.B. (2004) A role for MKP3 in axial patterning of the zebrafish embryo. Development (Cambridge, England). 131(12):2769-2779
Preger, E., Ziv, I., Shabtay, A., Sher, I., Tsang, M., Dawid, I.B., Altuvia, Y., and Ron, D. (2004) Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Proceedings of the National Academy of Sciences of the United States of America. 101(5):1229-1234
David, N.B., Saint-Etienne, L., Tsang, M., Schilling, T.F., and Rosa, F.M. (2002) Requirement for endoderm and FGF3 in ventral head skeleton formation. Development (Cambridge, England). 129(19):4457-4468
Tsang, M., Friesel, R., Kudoh, T., and Dawid, I.B. (2002) Identification of Sef, a novel modulator of FGF signalling. Nature cell biology. 4(2):165-169
Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. ZFIN Direct Data Submission.
Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. Genome research. 11(12):1979-1987
Chin, A.J., Tsang, M., and Weinberg, E.S. (2000) Heart and gut chiralities are controlled independently from initial heart position in the developing zebrafish. Developmental Biology. 227(2):403-421
Tsang, M., Kim, R., De Caestecker, M.P., Kudoh, T., Roberts, A.B., and Dawid, I.B. (2000) Zebrafish nma is involved in TGFb family signaling. Genesis (New York, N.Y. : 2000). 28(2):47-57
Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proceedings of the National Academy of Sciences of the United States of America. 96(17):9745-9750