ZFIN Person: Paw, Barry

ZFIN ID: ZDB-PERS-960805-432

ZFIN ID: ZDB-PERS-960805-432

Paw, Barry (Deceased)

URL:	http://paw-lab.bwh.harvard.edu
Affiliation:	Paw Lab
Address:	Division of Hematology-Oncology Department of Medicine Brigham and Women's Hospital and Boston Children's Hospital Harvard Medical School 77 Avenue Louis Pasteur HIM Building, Room 616 Boston, MA 02115-5727 USA
Country:	United States
Phone:	+1 617-525-4971
Fax:	+1 617-525-0040
ORCID ID:	0000-0002-0492-1419

BIOGRAPHY AND RESEARCH INTERESTS

Developmental biology of erythroid commitment and differentiation. Our research is focused on studying genes important for erythropoiesis. Using zebrafish as a model organism, we perform genetic screens to isolate anemic mutants. The disrupted genes are identified by positional cloning strategies. The functions of the identified genes are studied in zebrafish and complementary systems (cultured cells, transgenic mice, yeast).

PUBLICATIONS

Crispin, A., Guo, C., Chen, C., Campagna, D.R., Schmidt, P.J., Lichtenstein, D.A., Cao, C., Sendamarai, A.K., Hildick-Smith, G.J., Huston, N.C., Boudreaux, J., Bottomley, S.S., Heeney, M.M., Paw, B.H., Fleming, M.D., Ducamp, S. (2020) Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. The Journal of Clinical Investigation. 130(10):5245-5256

Yien, Y.Y., Shi, J., Chen, C., Cheung, J.T., Grillo, A.S., Shrestha, R., Li, L., Zhang, X., Kafina, M.D., Kingsley, P.D., King, M.J., Ablain, J., Li, H., Zon, L., Palis, J., Burke, M.D., Bauer, D.E., Orkin, S.H., Koehler, C.M., Phillips, J.D., Kaplan, J., Ward, D.M., Lodish, H.F., Paw, B.H. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of biological chemistry. 293(51):19797-19811

Kafina, M.D., Paw, B.H. (2018) Using the Zebrafish as an Approach to Examine the Mechanisms of Vertebrate Erythropoiesis. Methods in molecular biology (Clifton, N.J.). 1698:11-36

Seguin, A., Takahashi-Makise, N., Yien, Y.Y., Huston, N.C., Whitman, J.C., Musso, G., Wallace, J.A., Bradley, T., Bergonia, H., Kafina, M.D., Matsumoto, M., Igarashi, K., Phillips, J.D., Paw, B.H., Kaplan, J., Ward, D.M. (2017) Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes. The Journal of biological chemistry. 292(39):16284-16299

Kafina, M.D., Paw, B.H. (2017) Intracellular iron and heme trafficking and metabolism in developing erythroblasts.. Metallomics : integrated biometal science. 9(9):1193-1203

Yien, Y.Y., Ducamp, S., van der Vorm, L.N., Kardon, J.R., Manceau, H., Kannengiesser, C., Bergonia, H.A., Kafina, M.D., Karim, Z., Gouya, L., Baker, T.A., Puy, H., Phillips, J.D., Nicolas, G., Paw, B.H. (2017) Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.. Proceedings of the National Academy of Sciences of the United States of America. 114(38):E8045–E8052

Chung, J., Wittig, J.G., Ghamari, A., Maeda, M., Dailey, T.A., Bergonia, H., Kafina, M.D., Coughlin, E.E., Minogue, C.E., Hebert, A.S., Li, L., Kaplan, J., Lodish, H.F., Bauer, D.E., Orkin, S.H., Cantor, A.B., Maeda, T., Phillips, J.D., Coon, J.J., Pagliarini, D.J., Dailey, H.A., Paw, B.H. (2017) Erythropoietin signaling regulates heme biosynthesis. eLIFE. 6

Grillo, A.S., SantaMaria, A.M., Kafina, M.D., Cioffi, A.G., Huston, N.C., Han, M., Seo, Y.A., Yien, Y.Y., Nardone, C., Menon, A.V., Fan, J., Svoboda, D.C., Anderson, J.B., Hong, J.D., Nicolau, B.G., Subedi, K., Gewirth, A.A., Wessling-Resnick, M., Kim, J., Paw, B.H., Burke, M.D. (2017) Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science (New York, N.Y.). 356:608-616

van der Vorm, L.N., Paw, B.H. (2017) Studying disorders of vertebrate iron and heme metabolism using zebrafish. Methods in cell biology. 138:193-220

Shmukler, B.E., Lawson, N.D., Paw, B.H., Alper, S.L. (2016) Authors' response to "Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'". Haematologica. 101:e39

Anderson, H., Patch, T.C., Reddy, P.N., Hagedorn, E.J., Kim, P.G., Soltis, K.A., Chen, M.J., Tamplin, O.J., Frye, M., MacLean, G.A., Hübner, K., Bauer, D.E., Kanki, J.P., Vogin, G., Huston, N.C., Nguyen, M., Fujiwara, Y., Paw, B.H., Vestweber, D., Zon, L.I., Orkin, S.H., Daley, G.Q., Shah, D.I. (2015) Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 126(26):2811-20

Shmukler, B.E., Huston, N.C., Thon, J.N., Ni, C.W., Kourkoulis, G., Lawson, N.D., Paw, B.H., Alper, S.L. (2015) Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia. Haematologica. 100(12):e483-5

Yien, Y.Y., Ringel, A.R., Paw, B.H. (2015) Mitochondrial transport of protoporphyrinogen IX in erythroid cells. Oncotarget. 6:20742-3

Kardon, J.R., Yien, Y.Y., Huston, N.C., Branco, D.S., Hildick-Smith, G.J., Rhee, K.Y., Paw, B.H., Baker, T.A. (2015) Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. Cell. 161:858-867

Chung, J., Bauer, D.E., Ghamari, A., Nizzi, C.P., Deck, K.M., Kingsley, P.D., Yien, Y.Y., Huston, N.C., Chen, C., Schultz, I.J., Dalton, A.J., Wittig, J.G., Palis, J., Orkin, S.H., Lodish, H.F., Eisenstein, R.S., Cantor, A.B., Paw, B.H. (2015) The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Science signaling. 8:ra34

Yien, Y. Y., Robledo, R. F., Schultz, I. J., Takahashi-Makise, N., Gwynn, B., Bauer, D. E., Bass, A., Yi, G., Li, L., Hildick-Smith, G. J., Cooney, J. D., Pierce, E. L., Mohler, K., Dailey, T. A., Miyata, N., Kingsley, P. D., Garone, C., Hattangadi, S. M., Huang, H., Chen, W., Keenan, E. M., Shah, D. I., Schlaeger, T. M., DiMauro, S., Orkin, S. H., Cantor, A. B., Palis, J., Koehler, C. M., Lodish, H. F., Kaplan, J., Ward, D. M., Dailey, H. A., Phillips, J. D., Peters, L. L., Paw, B. H. (2014) TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124(10):4294-4304

Shmukler, B.E., Reimold, F.R., Heneghan, J.F., Chen, C., Zhao, T., Paw, B.H., Alper, S.L. (2014) Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Pflugers Archiv : European journal of physiology. 466(8):1605-18

Chung, J., Anderson, S.A., Gwynn, B., Deck, K.M., Chen, M.J., Langer, N.B., Shaw, G.C., Huston, N.C., Boyer, L.F., Datta, S., Paradkar, P.N., Li, L., Wei, Z., Lambert, A.J., Sahr, K., Wittig, J.G., Chen, W., Lu, W., Galy, B., Schlaeger, T.M., Hentze, M.W., Ward, D.M., Kaplan, J., Eisenstein, R.S., Peters, L.L., and Paw, B.H. (2014) Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria. The Journal of biological chemistry. 289(11):7835-7843

Hildick-Smith, G.J., Cooney, J.D., Garone, C., Kremer, L.S., Haack, T.B., Thon, J.N., Miyata, N., Lieber, D.S., Calvo, S.E., Akman, H.O., Yien, Y.Y., Huston, N.C., Branco, D.S., Shah, D.I., Freedman, M.L., Koehler, C.M., Italiano, J.E., Merkenschlager, A., Beblo, S., Strom, T.M., Meitinger, T., Freisinger, P., Donati, M.A., Prokisch, H., Mootha, V.K., Dimauro, S., and Paw, B.H. (2013) Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4. American journal of human genetics. 93(5):906-14

Pei, D., Luther, W., Wang, W., Paw, B.H., Stewart, R.A., and George, R.E. (2013) Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. PLoS Genetics. 9(6):e1003533

Harris, J.M., Esain, V., Frechette, G.M., Harris, L.J., Cox, A.G., Cortes, M., Garnaas, M.K., Carroll, K.J., Cutting, C.C., Khan, T., Elks, P.M., Renshaw, S.A., Dickinson, B.C., Chang, C.J., Murphy, M.P., Paw, B.H., Vander Heiden, M.G., Goessling, W., and North, T.E. (2013) Glucose metabolism impacts the spatio-temporal onset and magnitude of HSC induction in vivo. Blood. 121(13):2483-2493

Chen, C., Garcia-Santos, D., Ishikawa, Y., Seguin, A., Li, L., Fegan, K.H., Hildick-Smith, G.J., Shah, D.I., Cooney, J.D., Chen, W., King, M.J., Yien, Y.Y., Schultz, I.J., Anderson, H., Dalton, A.J., Freedman, M.L., Kingsley, P.D., Palis, J., Hattangadi, S.M., Lodish, H.F., Ward, D.M., Kaplan, J., Maeda, T., Ponka, P., and Paw, B.H. (2013) Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation. Cell Metabolism. 17(3):343-352

Cooney, J.D., Hildick-Smith, G.J., Shafizadeh, E., McBride, P.F., Carroll, K.J., Anderson, H., Shaw, G.C., Tamplin, O.J., Branco, D.S., Dalton, A.J., Shah, D.I., Wong, C., Gallagher, P.G., Zon, L.I., North, T.E., and Paw, B.H. (2013) Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology. 373(2):431-441

Shah, D.I., Takahashi-Makise, N., Cooney, J.D., Li, L., Schultz, I.J., Pierce, E.L., Narla, A., Seguin, A., Hattangadi, S.M., Medlock, A.E., Langer, N.B., Dailey, T.A., Hurst, S.N., Faccenda, D., Wiwczar, J.M., Heggers, S.K., Vogin, G., Chen, W., Chen, C., Campagna, D.R., Brugnara, C., Zhou, Y., Ebert, B.L., Danial, N.N., Fleming, M.D., Ward, D.M., Campanella, M., Dailey, H.A., Kaplan, J., and Paw, B.H. (2012) Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 491:608-612

Payne, E., Virgilio, M., Narla, A., Sun, H., Levine, M., Paw, B.H., Berliner, N., Look, A.T., Ebert, B., and Khanna-Gupta, A. (2012) L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood. 120(11):2214-2224

Leshchiner, I., Alexa, K., Kelsey, P., Adzhubei, I., Austin, C., Cooney, J., Anderson, H., King, M., Stottman, R., Ha, S., Drummond, I., Paw, B.H., North, T., Beier, D., Goessling, W., and Sunyaev, S. (2012) Mutation mapping and identification by whole genome sequencing. Genome research. 22(8):1541-1548

Blanc, L., Ciciotte, S.L., Gwynn, B., Hildick-Smith, G.J., Pierce, E.L., Soltis, K.A., Cooney, J.D., Paw, B.H., and Peters, L.L. (2012) Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 109(30):12099-12104

Wang, L., He, F., Bu, J., Liu, X., Du, W., Dong, J., Cooney, J.D., Dubey, S.K., Shi, Y., Gong, B., Li, J., McBride, P.F., Jia, Y., Lu, F., Soltis, K.A., Lin, Y., Namburi, P., Liang, C., Sundaresan, P., Paw, B.H., Li, D.Y., Phillips, J.D., and Yang, Z. (2012) ABCB6 Mutations Cause Ocular Coloboma. American journal of human genetics. 90(1):40-48

Wang, Y., Langer, N.B., Shaw, G.C., Yang, G., Li, L., Kaplan, J., Paw, B.H., and Bloomer, J.R. (2011) Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Experimental hematology. 39(7):784-94

Amigo, J.D., Yu, M., Troadec, M.B., Gwynn, B., Cooney, J.D., Lambert, A.J., Chi, N.C., Weiss, M.J., Peters, L.L., Kaplan, J., Cantor, A.B., and Paw, B.H. (2011) Identification of distal cis-regulatory elements at the mouse mitoferrin loci using zebrafish transgenesis. Molecular and cellular biology. 31(7):1344-56

Saslowsky, D.E., Cho, J.A., Chinnapen, H., Massol, R.H., Chinnapen, D.J., Wagner, J.S., De Luca, H.E., Kam, W., Paw, B.H., and Lencer, W.I. (2010) Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J. Clin. Invest.. 120(12):4399-4409

Yu, D., Dos Santos, C.O., Zhao, G., Jiang, J., Amigo, J.D., Khandros, E., Dore, L.C., Yao, Y., D'Souza, J., Zhang, Z., Ghaffari, S., Choi, J., Friend, S., Tong, W., Orange, J.S., Paw, B.H., and Weiss, M.J. (2010) miR-451 protects against erythroid oxidant stress by repressing 14-3-3ζ. Genes & Development. 24(15):1620-1633

Amigo, J.D., Ackermann, G.E., Cope, J.J., Yu, M., Cooney, J.D., Ma, D., Langer, N.B., Shafizadeh, E., Shaw, G.C., Horsley, W., Trede, N.S., Davidson, A.J., Barut, B.A., Zhou, Y., Wojiski, S.A., Traver, D., Moran, T.B., Kourkoulis, G., Hsu, K., Kanki, J.P., Shah, D.I., Lin, H.F., Handin, R.I., Cantor, A.B., and Paw, B.H. (2009) The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 114(21):4654-4663

Chen, W., Paradkar, P.N., Li, L., Pierce, E.L., Langer, N.B., Takahashi-Makise, N., Hyde, B.B., Shirihai, O.S., Ward, D.M., Kaplan, J., and Paw, B.H. (2009) Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 106(38):16263-16268

Sun, X., Hoage, T., Bai, P., Ding, Y., Chen, Z., Zhang, R., Huang, W., Jahangir, A., Paw, B., Li, Y.G., and Xu, X. (2009) Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One. 4(8):e6596

Nilsson, R., Schultz, I.J., Pierce, E.L., Soltis, K.A., Naranuntarat, A., Ward, D.M., Baughman, J.M., Paradkar, P.N., Kingsley, P.D., Culotta, V.C., Kaplan, J., Palis, J., Paw, B.H., and Mootha, V.K. (2009) Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metabolism. 10(2):119-130

Schwarz, K., Iolascon, A., Verissimo, F., Trede, N.S., Horsley, W., Chen, W., Paw, B.H., Hopfner, K.P., Holzmann, K., Russo, R., Esposito, M.R., Spano, D., De Falco, L., Heinrich, K., Joggerst, B., Rojewski, M.T., Perrotta, S., Denecke, J., Pannicke, U., Delaunay, J., Pepperkok, R., and Heimpel, H. (2009) Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nature Genetics. 41(8):936-940

Johnson, H.J., Gandhi, M.J., Shafizadeh, E., Langer, N.B., Pierce, E.L., Paw, B.H., Gilligan, D.M., and Drachman, J.G. (2009) The in vivo inactivation of MASTL kinase results in thrombocytopenia. Experimental hematology. 37(8):901-908

Stachura, D.L., Reyes, J.R., Bartunek, P., Paw, B.H., Zon, L.I., and Traver, D. (2009) Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood. 114(2):279-289

Freeman, J.L., Ceol, C., Feng, H., Langenau, D.M., Belair, C., Stern, H.M., Song, A., Paw, B.H., Look, A.T., Zhou, Y., Zon, L.I., and Lee, C. (2009) Construction and application of a zebrafish array comparative genomic hybridization platform. Genes, chromosomes & cancer. 48(2):155-170

Dobson, J.T., Seibert, J., Teh, E.M., Daas, S., Fraser, R.B., Paw, B.H., Lin, T.J., and Berman, J.N. (2008) Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. Blood. 112(7):2969-2972

Trede, N.S., Ota, T., Kawasaki, H., Paw, B.H., Katz, T., Demarest, B., Hutchinson, S., Zhou, Y., Hersey, C., Zapata, A., Amemiya, C.T., and Zon, L.I. (2008) Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(9):2575-2584

Dooley, K.A., Fraenkel, P.G., Langer, N.B., Schmid, B., Davidson, A.J., Weber, G., Chiang, K., Foott, H., Dwyer, C., Wingert, R.A., Zhou, Y., Paw, B.H., Zon, L.I., and Tübingen 2000 Screen Consortium . (2008) montalcino, A zebrafish model for variegate porphyria. Experimental hematology. 36(9):1132-1142

Rajagopal, A., Rao, A.U., Amigo, J., Tian, M., Upadhyay, S.K., Hall, C., Uhm, S., Mathew, M.K., Fleming, M.D., Paw, B.H., Krause, M., and Hamza, I. (2008) Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature. 453(7198):1127-1131

Woo, A.J., Moran, T.B., Schindler, Y., Choe, S.K., Langer, N.B., Sullivan, M.R., Fujiwara, Y., Paw, B.H., and Cantor, A.B. (2008) Identification of ZBP-89 as a Novel GATA-1 Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development. Molecular and cellular biology. 28(8):2675-2689

Dore, L.C., Amigo, J.D., Dos Santos, C.O., Zhang, Z., Gai, X., Tobias, J.W., Yu, D., Klein, A.M., Dorman, C., Wu, W., Hardison, R.C., Paw, B.H., and Weiss, M.J. (2008) A GATA-1-regulated microRNA locus essential for erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America. 105(9):3333-3338

Shmukler, B.E., Clark, J.S., Hsu, A., Vandorpe, D.H., Stewart, A.K., Kurschat, C.E., Choe, S.K., Zhou, Y., Amigo, J., Paw, B.H., and Alper, S.L. (2008) Zebrafish Ae2.2 encodes a second Slc4a2 anion exchanger. American journal of physiology. Regulatory, integrative and comparative physiology. 294(3):R1081-R1091

Paffett-Lugassy, N., Hsia, N., Fraenkel, P.G., Paw, B., Leschinsky, I., Barut, B., Bahary, N., Caro, J., Handin, R., and Zon, L.I. (2007) Functional conservation of erythropoietin signaling in zebrafish. Blood. 110(7):2718-2726

Trede, N.S., Medenbach, J., Damianov, A., Hung, L.H., Weber, G.J., Paw, B.H., Zhou, Y., Hersey, C., Zapata, A., Keefe, M., Barut, B.A., Stuart, A.B., Katz, T., Amemiya, C.T., Zon, L.I., and Bindereif, A. (2007) Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proceedings of the National Academy of Sciences of the United States of America. 104(16):6608-6613

Shaw, G.C., Cope, J.J., Li, L., Corson, K., Hersey, C., Ackermann, G.E., Gwynn, B., Lambert, A.J., Wingert, R.A., Traver, D., Trede, N.S., Barut, B.A., Zhou, Y., Minet, E., Donovan, A., Brownlie, A., Balzan, R., Weiss, M.J., Peters, L.L., Kaplan, J., Zon, L.I., and Paw, B.H. (2006) Mitoferrin is essential for erythroid iron assimilation. Nature. 440(7080):96-100

Lee, Y.M., Cope, J.J., Ackermann, G.E., Goishi, K., Armstrong, E.J., Paw, B.H., and Bischoff, J. (2006) Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(1):29-37

Lin, H.F., Traver, D., Zhu, H., Dooley, K., Paw, B.H., Zon, L.I., and Handin, R.I. (2005) Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood. 106(12):3803-3810

Shmukler, B.E., Kurschat, C.E., Ackermann, G.E., Jiang, L., Zhou, Y., Barut, B., Stuart-Tilley, A.K., Zhao, J., Zon, L.I., Drummond, I.A., Vandorpe, D.H., Paw, B.H., and Alper, S.L. (2005) Zebrafish slc4a2/ae2 Anion Exchanger: cDNA Cloning, Mapping, Functional Characterization, and Localization. American journal of physiology. Renal physiology. 289(4):F835-849

Wingert, R.A., Galloway, J.L., Barut, B., Foott, H., Fraenkel, P., Axe, J.L., Weber, G.J., Dooley, K., Davidson, A.J., Schmid, B., Paw, B.H., Shaw, G.C., Kingsley, P., Palis, J., Schubert, H., Chen, O., Kaplan, J., Zon, L.I., Tübingen 2000 Screen Consortium. (2005) Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature. 436(7053):1035-1039

Hsu, K., Traver, D., Kutok, J.L., Hagen, A., Liu, T.X., Paw, B.H., Rhodes, J., Berman, J., Zon, L.I., Kanki, J.P., and Look, A.T. (2004) The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 104(5):1291-1297

Shafizadeh, E., and Paw, B.H. (2004) Zebrafish as a model of human hematologic disorders. Current opinion in hematology. 11(4):255-261

Altmann, S.M., Mellon, M.T., Johnson, M.C., Paw, B.H., Trede, N.S., Zon, L.I., and Kim, C.H. (2004) Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio. Developmental and comparative immunology. 28(4):295-306

Ward, A.C., McPhee, D.O., Condron, M.M., Varma, S., Cody, S.H., Onnebo, S.M., Paw, B.H., Zon, L.I., and Lieschke, G.J. (2003) The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood. 102(9):3238-3240

Ackermann, G.E. and Paw, B.H. (2003) Zebrafish: a genetic model for vertebrate organogenesis and human disorders. Frontiers in bioscience : a journal and virtual library. 8:D1227-D1253

Paw, B.H., Davidson, A.J., Zhou, Y., Li, R., Pratt, S.J., Lee, C., Trede, N.S., Brownlie, A., Donovan, A., Liao, E.C., Ziai, J.M., Drejer, A.H., Guo, W., Kim, C.H., Gwynn, B., Peters, L.L., Chernova, M.N., Alper, S.L., Zapata, A., Wickramasinghe, S.N., Lee, M.J., Lux, S.E., Fritz, A., Postlethwait, J.H., and Zon, L.I. (2003) Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nature Genetics. 34(1):59-64

Brownlie, A., Hersey, C., Oates, A.C., Paw, B.H., Falick, A.M., Witkowska, H.E., Flint,J., Higgs, D., Jessen, J., Bahary, N., Zhu, H., Lin, S. and Zon, L. (2003) Characterization of embryonic globin genes of the zebrafish. Developmental Biology. 255(1):48-61

Donovan, A., Brownlie, A., Dorschner, M., Zhou, Y., Pratt, S.J., Paw, B.H., Thisse, C., Thisse, B., and Zon, L.I. (2002) The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood. 100:4655-4659

Shafizadeh, E., Paw, B.H., Foott, H., Liao, E.C., Barut, B.A., Cope, J.J., Zon, L.I., and Lin, S. (2002) Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency. Development (Cambridge, England). 129(18):4359-4370

Lieschke, G.J., Oates, A.C., Paw, B.H., Thompson, M.A., Hall, N.E., Ward, A.C., Ho, R.K., Zon, L.I., and Layton, J.E. (2002) Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Developmental Biology. 246(2):274-295

Ransom, D.G., Bahary, N., Paw, B.H., Saganic, W.J., Lim, C.A., Kingsley, P.D., Palis, J., Hersey, C., Zhou, Y., Barut, B.A., and Zon, L.I. (2001) Zebrafish moonshine encodes a transcriptional intermediary factor 1 ortholog that associates with GATA-1 and is required for normal hematopoiesis. Blood. 98(11):3294

Hsu, K., Rhodes, J., Liu, T.X., Kanki, J.P., Paw, B., Zon, L.I., and Look, A.T. (2001) Pu.1 is expressed by early granulocytic progenitors in the zebrafish. Blood. 98(11):63

Lin, H.F., Paw, B.H., Gregory, M., Jagadeeswaran, P., and Handin, R.I. (2001) Production and characterization of transgenic zebrafish (Danio rario) with fluorescent thrombocytes and thrombocyte precursors. Blood. 98(11):2147

Lin, H.F., Paw, B.H., Zon, L.I., and Handin, R.I. (2001) The analysis of thrombocyte development in zebrafish (Danio rario) harboring early hematopoietic or erythroid mutations. Blood. 98(11):283

Bennett, C.M., Kanki, J.P., Rhodes, J., Liu, T.X., Paw, B.H., Kieran, M.W., Langenau, D.M., Delahaye-Brown, A., Zon, L.I., Fleming, M.D., and Look, A.T. (2001) Myelopoiesis in the zebrafish, Danio rerio. Blood. 98(3):643-651

Paw, B.H. (2001) Cloning of the zebrafish retsina blood mutation: a genetic model for dyserythropoiesis and erythroid cytokinesis. Blood cells, molecules & diseases. 27(1):62-64

Liao, E.C., Paw, B.H., Peters, L.L., Zapata, A., Pratt, S.J., Do, C.P., Lieschke, G., and Zon, L.I. (2000) Hereditary spherocytosis in zebrafish riesling illustrates evolution of erythroid ß-spectrin structure, and function in red cell morphogenesis and membrane stability. Development (Cambridge, England). 127(23):5123-5132

Rhodes, J., Bennett, C.M., Kanki, J.P., Liu, T.X., Paw, B.H., Zon, L.I., and Look, A.T. (2000) Molecular analysis of zebrafish myelopoiesis. Blood. 96(11):3483

Trede, N.S., Ota, T., Kawasaki, H., Barut, B., Paw, B.H., Zhou, Y., Hersey, C., Zapata, A., Amemiya, C.T., and Zon, L.I. (2000) A genetic screen in the zebrafish defines mutations required for the development of the immune system. Blood. 96(11):2633

Paw, B.H., Zhou, Y., Li, R., Pratt, S.J., Davidson, A.J., Trede, N.S., Brownlie, A., Donovan, A., Liao, E.C., Drejer, A., Peters, L.L., Gwynn, B., Lux, S.E., and Zon, L.I. (2000) Cloning of the zebrafish Retsina blood mutation: Mutations in erythroid band 3 result in dyserythropoiesis and cytokinesis defects. Blood. 96(11):1895

Bennett, C.M., Fleming, M.D., Kanki, J.P., Rhodes, J., Delahaye-Brown, A., Langenau, D.M., Liu, T.X., Paw, B.H., Zon, L.I., and Look, A.T. (2000) Genetic analysis of myelopoiesis the zebrafish. Blood. 96(11):4177

Parichy, D.M., Ransom, D.G., Paw, B., Zon, L.I., and Johnson, S.L. (2000) An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development (Cambridge, England). 127(14):3031-3044

Paw, B.H. and Zon, L.I. (2000) Zebrafish: a genetic approach in studying hematopoiesis. Current opinion in hematology. 7(2):79-84

Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., Drejer, A., Barut, B., Zapata, A., Law, T.C., Brugnara, C., Lux, S.E., Pinkus, G.S., Pinkus, J.L., Kingsley, P.D., Palis, J., Fleming, M.D., Andrews, N.C., and Zon, L.I. (2000) Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 403(6771):776-781

Oates, A.C., Brownlie, A., Pratt, S.J., Irvine, D.V., Liao, E.C., Paw, B.H., Dorian, K.J., Johnson, S.L., Postlethwait, J.H., Zon, L.I., and Wilks, A.F. (1999) Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expresssion patterns: only jak2a is expressed during erythropoiesis. Blood. 94(8):2622-2636

Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proceedings of the National Academy of Sciences of the United States of America. 96(17):9745-9750

Oates, A.C., Wollberg, P., Pratt, S.J., Paw, B.H., Johnson, S.L., Ho, R.K., Postlethwait, J.H., Zon, L.I., and Wilks, A.F. (1999) Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1-deficient human cell line. Developmental Dynamics : an official publication of the American Association of Anatomists. 215(4):352-370

Paw, B.H. and Zon, L.I. (1999) Primary fibroblast cell culture. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:39-43

Brownlie, A., Donovan, A., Pratt, S.J., Paw, B.H., Oates, A.C., Brugnara, C., Witkowska, H.E., Sassa, S., and Zon, L.I. (1998) Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nature Genetics. 20:244-250

Kwok, C., Korn, R.M., Davis, M.E., Burt, D.W., Critcher, R., McCarthy, L., Paw, B.H., Zon, L.I., Goodfellow, P.N., and Schmitt, K. (1998) Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. Nucleic acids research. 26:3562-3566

Thompson, M.A., Ransom, D.G., Pratt, S.J., MacLennan, H., Kieran, M.W., Detrich,III, H.W., Vail, B., Huber, T.L., Paw, B., Brownlie, A.J., Oates, A.C., Fritz, A., Gates, MA., Amores, A., Bahary, N., Talbot, W.S., Her, H., Beier, D.R., Postlethwait, J.H., and Zon, L.I. (1998) The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Developmental Biology. 197:248-269

Jessen, J.R., Meng, A., McFarlane, R.J., Paw, B.H., Zon, L.I., Smith, G.R., and Lin, S. (1998) Modification of bacterial artificial chromosomes through Chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proceedings of the National Academy of Sciences of the United States of America. 95:5121-5126

Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349

Liao, E.C., Paw, B.H., Oates, A.C., Pratt, S.J., Postlethwait, J.H., and Zon, L.I. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes & Development. 12:621-626

Zon, L.I., Kieran, M., Paw, B., Thompson, M., Guo, W., Ransom, D., Brownlie, A., Chan, F.Y., Barone, L., McClennan, H., Ziegler, S., Pratt, S., and Detrich, H.W. III (1995) The zebrafish: a new model for studying embryonic hematopoiesis. In Ontogeny of hematopoiesis. Aplastic anemia, E. Gluckman, L. Coulombel, eds., Paris: Colloque INSERM/John Libbey Eurotext. 235:17-22

NON-ZEBRAFISH PUBLICATIONS
Blanc L, Ciciotte SL, Gwynn B, Hildick-Smith GJ, Pierce EL, Soltis KA, Cooney JD, Paw BH, Peters LL. Critical function for Rasa3 in vertebrate erythropoiesis and megakaryopoiesis. Proc. Natl. Acad. Sci. USA 2012; 109:12099-12104.

Troadec MB, Warner D, Wallace J, Thomas K, Spangrude G, Phillips J, Khalimonchuk O, Paw BH, Ward DM, Kaplan J. Targeted deletion of the mouse Mitoferrn1 gene: from anemia to protoporphyria. Blood 2011; 117:5494-5502. (Cover Illustration)

Saslowsky DE, Cho JA, Chinnapen H, Massol RH, Chinnapen DJF, Wagner JS, De Luca HE, Kam W, Paw BH, Lencer WI. Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins, but not Derlin-1 or -2. J. Clin. Invest. 2010; 120:4399-4409.

Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D’Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Wei T, Orange JS, Paw BH, Weiss MJ. miR-451 protects against erythroid oxidant stress by repressing 14-3-3ζ. Genes Dev. 2010; 24:1620-33.

Chen W, Dailey HA, Paw BH. Ferrochelatase forms an oligomeric complex with mitoferrin1 and Abcb10 for erythroid heme biosynthesis. Blood 2010; 116:628-30.