ZFIN ID: ZDB-GENE-990415-163
Gene Name: myocyte enhancer factor 2aa
Gene Symbol: mef2aa    Nomenclature History

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Previous Names: mef2a, etID309779.18 (1), wu:fd19d02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including myofibril assembly; positive regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to localize to nuclear chromatin. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is expressed in cardiovascular system; myotome; nervous system; pharyngeal arch; and somite. Orthologous to human MEF2A (myocyte enhancer factor 2A).
Genome Resources: Alliance (1),  Gene:30564 (1),  Ensembl(GRCz11):ENSDARG00000031756 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020336Tg Transgenic Insertion Unknown Unknown DNA
sa29039 Point Mutation Unknown Premature Stop ENU
sa43112 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mef2aa N/A 4
    MO2-mef2aa N/A 3
    MO3-mef2aa N/A 1
    MO4-mef2aa N/A 1
    DISEASE ASSOCIATED WITH mef2aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    coronary artery disease Alliance {Coronary artery disease, autosomal dominant, 1} 608320
    DISEASE ASSOCIATED WITH mef2aa VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mef2aa-201 (1)    Ensembl 1736
    mef2aa-202 (1)    Ensembl 1844
    mef2aa-204 (1)    Ensembl 1733
    mef2aa-205 (1)    Ensembl 2113
    ncRNA mef2aa-005 (1) 606
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-mef2 polyclonal IgG Rabbit IHC AnaSpec
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mef2aa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(mef2aa:EGFP) mef2aa EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    mef2aa Contained in: [BAC] CH211-212B13 (1), DKEYP-96F6 (1)
    mef2aa Encodes: [EST] fd19d02
    [cDNA] MGC:55208 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131301 (1) 2070 nt
    Genomic GenBank:AL953894 (1) 222376 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LXH4 (1) 524 aa
    Sequence Information (all 53)
    ORTHOLOGY for mef2aa ( Chr: 18 )
    CITATIONS (61)