ZFIN Gene: mef2ca

ZFIN ID: ZDB-GENE-980526-253

ZFIN ID: ZDB-GENE-980526-253

Gene Name:

myocyte enhancer factor 2ca

Gene Symbol:

mef2ca

Sequence Ontology ID :

SO:0000704

Previous Names:

mef2c, hoo, hoover, id:ibd5026, wu:fc05b06, zgc:64184, zgc:85726

Location:

Chr: 10 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits transcription regulatory region sequence-specific DNA binding activity; involved in several processes, including animal organ development, ligamentous ossification, and positive regulation ...

GENE EXPRESSION
All Expression Data:	38 figures from 23 publications
Directly Submitted Expression Data:	6 figures (15 images) from Thisse et al., 2004 [MGC:85726]
	2 figures (3 images) from Kudoh et al., 2001 [ibd5026]
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
	adaxial cell anterior commissure anterior lateral plate mesoderm heart primordium anterior lateral plate mesoderm atrium brain cardiac ventricle cerebellum cleithrum cranial neural crest diencephalon dorsal telencephalon fast muscle cell heart heart primordium heart rudiment heart tube hindbrain hypaxial myotome region integument kidney midbrain muscle muscle cell myotome skeletal muscle cell myotome olfactory epithelium opercular flap optic tectum pectoral fin pectoral fin bud pectoral fin musculature pharyngeal arch pharyngeal arch 3-7 pharyngeal arch 3-7 skeleton pharyngeal musculature presumptive atrium heart tube presumptive cardiac ventricle heart tube primitive heart tube skeletal muscle cell slow muscle cell somite somite border telencephalon ventral mandibular arch vertebra whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
b631	Point Mutation	Unknown	Missense		Zebrafish International Resource Center (ZIRC) (order this)
b1086	Point Mutation	Exon 2	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa2569	Point Mutation	Unknown	Splice Site	ENU
sa31806	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34988	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa34989	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tn213	Point Mutation	Donor Splice Site of Intron 7	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)

Targeting reagents:

PHENOTYPE

Data:

14 figures from 8 publications

Observed in:

DISEASE ASSOCIATED WITH mef2ca HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
autosomal dominant mental retardation 20	Chromosome 5q14.3 deletion syndrome	613443
	Mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations	613443

DISEASE ASSOCIATED WITH mef2ca VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	positive regulation of transcription by RNA polymerase II (more)
Cellular Component	nucleus (more)
Molecular Function	transcription regulatory region sequence-specific DNA binding (more)

GO Terms (all 19)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR002100 (1) InterPro:IPR022102 (1) InterPro:IPR033896 (1) InterPro:IPR036879 (1)	PROSITE:PS00350 (1) PROSITE:PS50066 (1)	Pfam:PF00319 (1) Pfam:PF12347 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	mef2ca-201	3502	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mef2ca-203	3567	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mef2ca-204	6164	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mef2ca-205	393	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mef2ca-206	318	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	mef2ca-207	393	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES

Ab2-mef2 (1)
Ab2-mef2c (1)

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM mef2ca No data available

MARKER RELATIONSHIPS

mef2caContained in:	[BAC] CH73-215F7 (1) (order this) [Fosmid] CH1073-234A2 (1) (order this), CH1073-412J12 (1) (order this), CH1073-418F12 (1) (order this)
mef2caEncodes:	[EST] fc05b06, ibd5026 (order this) [cDNA] MGC:64184 (1) (order this), MGC:85726 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131312 (1)	4315bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU462873 (1)	95788bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6NSN7 (1)	491aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:3182 (1)

Sequence Information (all 60)

OTHER mef2ca GENE PAGES

Alliance (1)

Gene:30575 (1)

VEGA:OTTDARG00000030787 (1)

Ensembl(GRCz11):ENSDARG00000029764 (2)

ORTHOLOGY for mef2ca (Chr: 10)

CITATIONS (84)

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