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ZFIN ID: ZDB-GENE-980526-90
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Gene Name: achaete-scute family bHLH transcription factor 1a
Gene Symbol: ascl1a    Nomenclature History

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Previous Names: asha, Zash-1a (1), zash1a, id:ibd5085 (1), pia, pituitary absent, zasha

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including animal organ development; epithelial cell differentiation; and regulation of gene expression. Predicted to localize to the RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Is expressed in several structures, including digestive system; nervous system; neural tube; neuronal stem cell; and optic cup. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1).
Genome Resources: Alliance (1),  Gene:30466 (1),  Ensembl(GRCz11):ENSDARG00000038386 (2)
GENE EXPRESSION
All Expression Data: 131 figures from 79 publications
Directly Submitted Expression Data: 3 figures (4 images) from Kudoh et al., 2001 [ibd5085]
  6 figures (16 images) from Thisse et al., 2005 [eu887]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ascl1a_unspecified Unspecified Unknown Unknown
t25215 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ascl1a
1
CRISPR2-ascl1a
1
CRISPR3-ascl1a
1
CRISPR4-ascl1a
1
CRISPR5-ascl1a
1
CRISPR6-ascl1a
1
MO1-ascl1a N/A 15
MO2-ascl1a N/A 13
MO3-ascl1a N/A 6
MO4-ascl1a N/A 1
PHENOTYPE
Data: 14 figures from 8 publications
Observed in:
DISEASE ASSOCIATED WITH ascl1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital 209880
Haddad syndrome 209880
DISEASE ASSOCIATED WITH ascl1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 30)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • InterPro:IPR015660 (1)
  • InterPro:IPR036638 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ascl1a-201 (1)    Ensembl 1977
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ascl1 polyclonal Rabbit IHC Sigma-Aldrich
    		3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ascl1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-4.5ascl1a:EGFP) ascl1a EGFP Danio rerio 1 2
    Tg(-6ascl1a:EGFP) ascl1a EGFP Danio rerio 1 2
    Tg(ascl1a:EGFP) ascl1a EGFP Danio rerio 1 5
    Tg(hsp70l:FLAG-MYC-ascl1a,-1.0Cau.Tuba1:GFP) hsp70l ascl1a,  FLAG,  GFP,  MYC Carassius auratus,  Danio rerio 1 1
    Tg2(-6ascl1a:EGFP) ascl1a EGFP Danio rerio 1 2
    Tg3(-6ascl1a:EGFP) ascl1a EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    ascl1a Contained in: [BAC] CH211-260P3 (1) (order this), DKEY-264K15 (1) (order this)
    ascl1a Encodes: [EST] eu887 (1), ibd5085 (1) (order this)
    [cDNA] MGC:109810 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131219 (1) 1561 bp
    Select Tool
    Genomic GenBank:BX511171 166242 bp
    Select Tool
    Polypeptide UniProtKB:Q90259 (1) 196 aa
    Select Tool
    Sequence Clusters UniGene:314 (1)
    Sequence Information (all 17)
    ORTHOLOGY for ascl1a ( Chr: 4 )
    CITATIONS (169)