ZFIN ID: ZDB-GENE-980526-6
Gene Name: engrailed homeobox 1b
Gene Symbol: en1b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: eng1b, eng4, engrailed 4, wu:fc84e11, zgc:113499

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation and neuron fate commitment. Predicted to localize to the RSC-type complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in muscle; nervous system; and neural tube. Orthologous to human EN1 (engrailed homeobox 1).
Genome Resources: Alliance (1),  Gene:541371 (1),  Ensembl(GRCz11):ENSDARG00000098730 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3426 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nns40Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    nns55Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    nns58Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    sa100 Point Mutation Unknown Unknown ENU
    sa19415 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-en1b
    1
    CRISPR2-en1b
    1
    CRISPR3-en1b
    1
    CRISPR4-en1b
    1
    CRISPR5-en1b 2
    MO1-en1b N/A 1
    MO2-en1b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH en1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH en1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis involved in innervation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017970 Homeobox, conserved site
    Conserved_site IPR019737 Homeobox engrailed-type, conserved site
    Domain IPR000747 Homeobox domain engrailed
    Domain IPR001356 Homeobox domain
    Domain IPR019549 Homeobox engrailed, C-terminal
    Domain IPR020479 Homeobox domain, metazoa
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA en1b-201 (1)    Ensembl 781
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-eng monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
    110
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM en1b No data available
    MARKER RELATIONSHIPS
    en1b Contained in: [BAC] CH73-252H6 (1), CH211-190D13 (1)
    en1b Encodes: [EST] fc84e11, IMAGE:7138514 (1)
    [cDNA] MGC:113499 (1), MGC:192625 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013498 (1) 1605 nt
    Genomic GenBank:BX908756 (1) 134952 nt
    Select Tool
    Polypeptide UniProtKB:Q5BJ08 (1) 274 aa
    Sequence Information (all 22)
    ORTHOLOGY for en1b ( Chr: 1 )
    CITATIONS (59)