Gene

en1b

ID
ZDB-GENE-980526-6
Name
engrailed homeobox 1b
Symbol
en1b Nomenclature History
Previous Names
  • eng1b
  • eng4
  • engrailed 4
  • wu:fc84e11
  • zgc:113499
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation and neuron fate commitment. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in myoseptum; nervous system; neural tube; and somite. Orthologous to human EN1 (engrailed homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With en1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?ENDOVE syndrome, limb-brain type 619218
Associated With en1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Conserved_site IPR019737 Homeobox engrailed-type, conserved site
Domain IPR000747 Homeobox domain engrailed
Domain IPR001356 Homeobox domain
Domain IPR019549 Homeobox engrailed, C-terminal
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain engrailed Homeobox domain, metazoa Homeobox engrailed, C-terminal Homeobox engrailed-type, conserved site Homeobox-like domain superfamily
UniProtKB:A0A0R4IKF8 168
UniProtKB:Q9YGU2 259
UniProtKB:Q5BJ08 274
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-eng monoclonal IgG1 , k Mouse
  • IHC
Developmental Studies Hybridoma Bank
116
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations