Gene

en1a

ID
ZDB-GENE-980526-216
Name
engrailed homeobox 1a
Symbol
en1a Nomenclature History
Previous Names
  • en-1
  • en1
  • eng1 (1)
  • eng1a
  • zgc:100771
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Orthologous to human EN1 (engrailed homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
41 figures from 25 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With en1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?ENDOVE syndrome, limb-brain type 619218
Associated With en1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Conserved_site IPR019737 Homeobox engrailed-type, conserved site
Domain IPR000747 Homeobox domain engrailed
Domain IPR001356 Homeobox domain
Domain IPR019549 Homeobox engrailed, C-terminal
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain engrailed Homeobox domain, metazoa Homeobox engrailed, C-terminal Homeobox engrailed-type, conserved site Homeobox-like domain superfamily
UniProtKB:Q68EL7 231
UniProtKB:Q04896 231
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-eng monoclonal IgG1 , k Mouse
  • IHC
Developmental Studies Hybridoma Bank
116
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations