ZFIN ID: ZDB-GENE-980526-216
Gene Name: engrailed homeobox 1a
Gene Symbol: en1a    Nomenclature History

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Previous Names: en-1, en1, eng1 (1), eng1a, zgc:100771

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation. Predicted to localize to the RSC-type complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Orthologous to human EN1 (engrailed homeobox 1).
Genome Resources: Alliance (1),  Gene:30244 (1),  Ensembl(GRCz11):ENSDARG00000014321 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-en1a N/A 1
MO2-en1a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH en1a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH en1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process axonogenesis involved in innervation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Domain IPR000747 Homeobox domain engrailed
Domain IPR001356 Homeobox domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR019549 Homeobox engrailed, C-terminal
Conserved_site IPR019737 Homeobox engrailed-type, conserved site
Domain IPR020479 Homeobox domain, metazoa
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-eng monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
108
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM en1a No data available
MARKER RELATIONSHIPS
en1a Encodes: [EST] IMAGE:7138684 (1)
[cDNA] MGC:100771 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131045 (1)
Polypeptide UniProtKB:Q04896 (1) 231 aa
Sequence Information (all 13)
ORTHOLOGY for en1a ( Chr: 9 )
CITATIONS (66)