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ZIRC
ZFIN ID: ZDB-GENE-980526-40
Gene Name: engrailed homeobox 2b
Gene Symbol: en2b    Nomenclature History

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Previous Names: en3 (1), eng2b, eng3 (1), engrailed 3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to localize to the RSC-type complex. Human ortholog(s) of this gene implicated in autistic disorder. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Orthologous to human EN2 (engrailed homeobox 2).
Genome Resources: Alliance (1),  Gene:30238 (1),  Ensembl(GRCz11):ENSDARG00000038868 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-en2b N/A 4
PHENOTYPE No data available
DISEASE ASSOCIATED WITH en2b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH en2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process anterior/posterior pattern specification (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 12)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA en2b-201 (1)    Ensembl 1825
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-eng monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
108
Ab2-eng polyclonal Rabbit IHC 4
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM en2b No data available
MARKER RELATIONSHIPS
en2b Contained in: [BAC] DKEY-265A7 (1) (order this)
en2b Encodes: [EST] IMAGE:7141696 (1) (order this)
[cDNA] MGC:86574 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131040 (1) 1823 bp
Genomic GenBank:BX510360 (1) 213323 bp Blast at MegaBLAST
Polypeptide UniProtKB:A3KPY2 (1) 261 aa
Sequence Clusters UniGene:498 (1)
Sequence Information (all 16)
ORTHOLOGY for en2b ( Chr: 2 )
CITATIONS (84)