ZFIN ID: ZDB-GENE-980526-167
Gene Name: engrailed homeobox 2a
Gene Symbol: en2a    Nomenclature History

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Previous Names: eng2 (1), eng2a, Zf-en (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in apoptotic process involved in morphogenesis; cell fate specification; and nervous system development. Predicted to localize to the RSC-type complex. Human ortholog(s) of this gene implicated in autistic disorder. Is expressed in several structures, including adaxial cell; central nervous system; muscle; neural plate; and pharyngeal arch. Orthologous to human EN2 (engrailed homeobox 2).
Genome Resources: Alliance (1),  Gene:30243 (1),  Ensembl(GRCz11):ENSDARG00000026599 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-en2a N/A 5
MO2-en2a N/A 1
MO3-en2a N/A 1
PHENOTYPE
Data: Fig. 1 from Scholpp et al., 2001
Observed in:
DISEASE ASSOCIATED WITH en2a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH en2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process anterior/posterior pattern specification (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Domain IPR000747 Homeobox domain engrailed
Domain IPR001356 Homeobox domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR019549 Homeobox engrailed, C-terminal
Conserved_site IPR019737 Homeobox engrailed-type, conserved site
Domain IPR020479 Homeobox domain, metazoa
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA en2a-201 (1)    Ensembl 2910
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-eng monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
108
Ab2-eng polyclonal Rabbit IHC 4
CONSTRUCTS WITH SEQUENCES FROM en2a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-8en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg(-10en2a:EGFP) en2a EGFP Danio rerio 1 8
Tg1(en2a:EGFP) en2a EGFP Danio rerio 2 3
Tg2(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg3(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg4(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg5(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg6(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg7(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg8(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg9(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg10(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg11(en2a:EGFP) en2a EGFP Danio rerio 1 2
Tg12(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg13(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg14(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg15(en2a:EGFP) en2a EGFP Danio rerio 1 3
Tg16(en2a:EGFP) en2a EGFP Danio rerio 1 2
MARKER RELATIONSHIPS
en2a Contained in: [BAC] CH211-105D1 (1), CH211-150E22 (1)
en2a Encodes: [EST] eu759 (1)
[cDNA] MGC:193941 (1), MGC:193943 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131044 (1) 2607 bp
Genomic GenBank:CU041319 (1) 174262 bp
Select Tool
Polypeptide UniProtKB:B3DGA1 (1) 265 aa
Sequence Clusters UniGene:162132 (1)
Sequence Information (all 28)
ORTHOLOGY for en2a ( Chr: 7 )
CITATIONS (161)