Gene
rarga
- ID
- ZDB-GENE-980526-531
- Name
- retinoic acid receptor gamma a
- Symbol
- rarga Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity. Involved in liver development and pharyngeal system development. Predicted to localize to RNA polymerase II transcription factor complex. Is expressed in several structures, including central nervous system; germ ring; gonad; mesoderm; and neural crest. Orthologous to human RARG (retinoic acid receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 23 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- s74156 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010912Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la014420Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la014421Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022698Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022699Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la022701Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028558Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028559Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa32460 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-rarga | N/A | (6) |
MO2-rarga | N/A | Samarut et al., 2014 |
MO3-rarga | N/A | Kalaskar et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
Domain | IPR047158 | Retinoic acid receptor, ligand-binding domain |
Domain | IPR047159 | Retinoic acid receptor, DNA-binding domain |
Family | IPR001723 | Nuclear hormone receptor |
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Domain Details Per Protein
Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoic acid receptor | Retinoic acid receptor, DNA-binding domain | Retinoic acid receptor, ligand-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q91392
|
499 |
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Interactions and Pathways
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-43N10 | ZFIN Curated Data | |
Contained in | BAC | DKEY-148F24 | ZFIN Curated Data | |
Encodes | EST | fb01e02 | ZFIN Curated Data | |
Encodes | EST | fb01f03 | ||
Encodes | EST | fc35a09 | ZFIN Curated Data | |
Encodes | EST | s74156 | Bertrand et al., 2007 | |
Encodes | cDNA | MGC:109801 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131339 (1) | 3647 nt | ||
Genomic | GenBank:BX465864 (1) | 128483 nt | ||
Polypeptide | UniProtKB:Q91392 (1) | 499 aa |
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Sojan, J.M., Gioacchini, G., Giorgini, E., Orlando, P., Tiano, L., Maradonna, F., Carnevali, O. (2022) Zebrafish caudal fin as a model to investigate the role of probiotics in bone regeneration. Scientific Reports. 12:8057
- Cao, Z., Meng, Y., Gong, F., Xu, Z., Liu, F., Fang, M., Zou, L., Liao, X., Wang, X., Luo, L., Li, X., Lu, H. (2021) Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration. Proceedings of the National Academy of Sciences of the United States of America. 118(2):
- Iwanami, N., Takeshita, K., Lawir, D.F., Suetake, I., Tajima, S., Sikora, K., Trancoso, I., ÓMeara, C., Siamishi, I., Takahama, Y., Furutani-Seiki, M., Kondoh, H., Yonezawa, Y., Schorpp, M., Boehm, T. (2020) Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. iScience. 23:101260
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Kalaskar, V.K., Alur, R.P., Li, L.K., Thomas, J.W., Sergeev, Y.V., Blain, D., Hufnagel, R.B., Cogliati, T., Brooks, B.P. (2019) High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Human Mutation. 41(3):678-695
- Kaur, N., Chugh, H., Tomar, V., Sakharkar, M.K., Dass, S.K., Chandra, R. (2019) Cinnamon attenuates adiposity and affects the expression of metabolic genes in Diet-Induced obesity model of zebrafish. Artificial cells, nanomedicine, and biotechnology. 47:2930-2939
- Chawla, B., Swain, W., Williams, A.L., Bohnsack, B.L. (2018) Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish. Investigative ophthalmology & visual science. 59:1924-1935
- Qin, C., Xie, Y., Wang, Y., Li, S., Ran, C., He, S., Zhou, Z. (2018) Impact of Lactobacillus casei BL23 on the Host Transcriptome, Growth and Disease Resistance in Larval Zebrafish.. Frontiers in Physiology. 9:1245
- Xiong, X.Y., Liu, Y., Shan, L.T., Xu, Y.Q., Liang, J., Lai, Y.H., Hsiao, C.D. (2018) Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration. Biochemical and Biophysical Research Communications. 505(2):516-522
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