ZFIN ID: ZDB-LAB-130607-1
European Zebrafish Resource Center (EZRC)
PI/Director: Geisler, Robert
Strähle, Uwe
Contact Person:
Email: sybille.kuerner-winkeler@kit.edu
URL: http://www.ezrc.kit.edu
Address: Delivery address Karlsruher Institut für Technologie (KIT) Institut für Toxikologie und Genetik (ITG) Campus Nord Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany Mailing address Karlsruher Institut für Technologie (KIT) Institut für Toxikologie und Genetik (ITG) Campus Nord Postfach 3640 76021 Karlsruhe Germany
Country: Germany
Phone: +49 721 608-23291
Fax: +49 721 608-23354
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LABNo data available


STATEMENT OF RESEARCH INTERESTS
Zebrafish (Danio rerio) and medaka (Oryzias latipes) are small fish that offer a rich repertoire of genetic, molecular and cellular manipulation tools that are of central importance for the BioInterfaces programme. Their unique properties (small size, numerous offspring, optical transparency of the embryo, amenability to genetic and chemical screens) make them ideal for the identification in vivo of new key targets and small molecules that control cell behaviour. Indeed they are currently the only vertebrate system that permit screens of phenotypic changes in response to genetic alterations or small molecules to be made efficiently. Moreover, the transparency and small size of the embryos allow the monitoring and modelling of cell behaviour underlying vertebrate development and organ formation, unique features not offered by other vertebrate models and of central importance for the BioInterfaces programme. The availability of several thousand existing mutants and transgenic lines is also a vital resource. Small fish models are invaluable for many fields, including cell biology, developmental genetics and biomedicine. As a consequence, the pharmaceutical industry is strongly interested in using fish for drug screens and whole animal toxicology studies.

The KIT houses the largest experimental fish facility in Europe with a capacity of more than 300.000 fish. The facility is now being further enlarged to serve as a European Zebrafish Resource Center (EZRC). This center will be unique as it will not only maintain and distribute a large number of existing mutant and transgenic zebrafish lines but will also provide screening services and technologies such as imaging and high-throughput sequencing. In close interaction with physicists, engineers and IT specialists, we are actively expanding the medium/high throughput screening technologies that have been recently established at KIT. Key areas include automation of embryo handling and automated image acquisition and processing. Our platform also involves the development of novel microscopy techniques, (e.g. SPIM, DSLM, robotic macroscope) to permit high-resolution, real-time imaging in 4D. Furthermore, computational methods pave the way for virtual screens where researchers anywhere in the world will be able to link into the EZRC database to access the high resolution models of wild-type, transgenic, mutant and chemically exposed embryos for particular traits of interest.

In addition the fish facility keeps a range of medaka stocks, maintained by the Loosli group.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Shimizu, H., Langenbacher, A.D., Huang, J., Wang, K., Otto, G., Geisler, R., Wang, Y., Chen, J.N. (2017) The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. eLIFE. 6
Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991
Geisler, R., Köhler, A., Dickmeis, T., Strähle, U. (2017) Archiving of zebrafish lines can reduce animal experiments in biomedical research. EMBO reports. 18(1):1-2
Angelin, A., Kassel, O., Rastegar, S., Strähle, U., Niemeyer, C.M. (2016) Protein-Functionalized DNA Nanostructures as Tools to Control Transcription in Zebrafish Embryos. ChemistryOpen. 6:33-39
Lopes, S.S., Distel, M., Linker, C., Fior, R., Monteiro, R., Bianco, I.H., Portugues, R., Strähle, U., Saúde, L. (2016) Report of the 4th European Zebrafish Principal Investigator Meeting. Zebrafish. 13(6):590-595
Valentim, A.M., van Eeden, F.J., Strähle, U., Olsson, I.A. (2016) Euthanizing zebrafish legally in Europe: Are the approved methods of euthanizing zebrafish appropriate to research reality and animal welfare?. EMBO reports. 17(12):1688-1689
Stoetzel, C., Bär, S., De Craene, J.O., Scheidecker, S., Etard, C., Chicher, J., Reck, J.R., Perrault, I., Geoffroy, V., Chennen, K., Strähle, U., Hammann, P., Friant, S., Dollfus, H. (2016) A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. Nature communications. 7:13586
Middel, V., Zhou, L., Takamiya, M., Beil, T., Shahid, M., Roostalu, U., Grabher, C., Rastegar, S., Reischl, M., Nienhaus, G.U., Strähle, U. (2016) Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair. Nature communications. 7:12875
Hilinski, W.C., Bostrom, J.R., England, S.J., Juárez-Morales, J.L., de Jager, S., Armant, O., Legradi, J., Strähle, U., Link, B.A., Lewis, K.E. (2016) Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Development. 11:16
Rudeck, S., Etard, C., Khan, M.M., Rottbauer, W., Rudolf, R., Strähle, U., Just, S. (2016) A compact unc45b-promoter drives muscle-specific expression in zebrafish and mouse. Genesis (New York, N.Y. : 2000). 54(8):431-8
Geisler, R., Borel, N., Ferg, M., Maier, J.V., Strähle, U. (2016) Maintenance of Zebrafish Lines at the European Zebrafish Resource Center. Zebrafish. 13 Suppl 1:S19-23
Frohnhöfer, H.G., Geiger-Rudolph, S., Pattky, M., Meixner, M., Huhn, C., Maischein, H.M., Geisler, R., Gehring, I., Maderspacher, F., Nüsslein-Volhard, C., Irion, U. (2016) Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish. Biology Open. 5(6):736-44
Strähle, U., Ferg, M., Armant, O., Gradl, M., Kaufmann, L., Rastegar, S. (2016) HeRBi: Helmholtz Repository of Bioparts. Zebrafish. 13(3):234-5
Armant, O., Gourain, V., Etard, C., Strähle, U. (2016) Whole transcriptome data analysis of zebrafish mutants affecting muscle development. Data in brief. 8:61-8
Takamiya, M., Xu, F., Suhonen, H., Gourain, V., Yang, L., Ho, N.Y., Helfen, L., Schröck, A., Etard, C., Grabher, C., Rastegar, S., Schlunck, G., Reinhard, T., Baumbach, T., Strähle, U. (2016) Melanosomes in pigmented epithelia maintain eye lens transparency during zebrafish embryonic development. Scientific Reports. 6:25046
Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016) Zebrafish biosensor for toxicant induced muscle hyperactivity. Scientific Reports. 6:23768
Rastegar, S., Strähle, U. (2016) The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes. Advances in genetics. 95:195-216
Etard, C., Armant, O., Roostalu, U., Gourain, V., Ferg, M., Strähle, U. (2015) Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome biology. 16:267
Hausen, J., Otte, J.C., Strähle, U., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R. (2015) Fold-change threshold screening: a robust algorithm to unmask hidden gene expression patterns in noisy aggregated transcriptome data. Environmental science and pollution research international. 22(21):16384-92
Diotel, N., Beil, T., Strähle, U., Rastegar, S. (2015) Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis. Gene Expression Patterns. 19(1-2):1-13
Carmean, V., Yonkers, M.A., Tellez, M.B., Willer, J.R., Willer, G.B., Gregg, R.G., Geisler, R., Neuhauss, S.C., Ribera, A.B. (2015) pigk mutation underlies macho behavior and affects Rohon-Beard cell excitability. Journal of neurophysiology. 114(2):1146-57
Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
Naville, M., Ishibashi, M., Ferg, M., Bengani, H., Rinkwitz, S., Krecsmarik, M., Hawkins, T.A., Wilson, S.W., Manning, E., Chilamakuri, C.S., Wilson, D.I., Louis, A., Lucy Raymond, F., Rastegar, S., Strähle, U., Lenhard, B., Bally-Cuif, L., van Heyningen, V., FitzPatrick, D.R., Becker, T.S., Roest Crollius, H. (2015) Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. Nature communications. 6:6904
Scheidecker, S., Etard, C., Haren, L., Stoetzel, C., Hull, S., Arno, G., Plagnol, V., Drunat, S., Passemard, S., Toutain, A., Obringer, C., Koob, M., Geoffroy, V., Marion, V., Strähle, U., Ostergaard, P., Verloes, A., Merdes, A., Moore, A.T., Dollfus, H. (2015) Mutations in TUBGCP4 Alter Microtubule Organization via the γ-Tubulin Ring Complex in Autosomal-Recessive Microcephaly with Chorioretinopathy. American journal of human genetics. 96(4):666-74
Rodriguez Viales, R., Diotel, N., Ferg, M., Armant, O., Eich, J., Alunni, A., März, M., Bally-Cuif, L., Rastegar, S., Strähle, U. (2015) The helix-loop-helix protein Id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon. Stem Cells. 33(3):892-903
Kobitski, A.Y., Otte, J.C., Takamiya, M., Schäfer, B., Mertes, J., Stegmaier, J., Rastegar, S., Rindone, F., Hartmann, V., Stotzka, R., García, A., van Wezel, J., Mikut, R., Strähle, U., Nienhaus, G.U. (2015) An ensemble-averaged, cell density-based digital model of zebrafish embryo development derived from light-sheet microscopy data with single-cell resolution. Scientific Reports. 5:8601
Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
Bluhm, K., Otte, J.C., Yang, L., Zinsmeister, C., Legradi, J., Keiter, S., Kosmehl, T., Braunbeck, T., Strähle, U., Hollert, H. (2014) Impacts of Different Exposure Scenarios on Transcript Abundances in Danio rerio Embryos when Investigating the Toxicological Burden of Riverine Sediments. PLoS One. 9:e106523
Schmidt, R., Beil, T., Strähle, U., Rastegar, S. (2014) Stab wound injury of the zebrafish adult telencephalon: a method to investigate vertebrate brain neurogenesis and regeneration. Journal of visualized experiments : JoVE. (90):e51753
Haberle, V., Li, N., Hadzhiev, Y., Plessy, C., Previti, C., Nepal, C., Gehrig, J., Dong, X., Akalin, A., Suzuki, A.M., van IJcken, W.F., Armant, O., Ferg, M., Strähle, U., Carninci, P., Müller, F., and Lenhard, B. (2014) Two independent transcription initiation codes overlap on vertebrate core promoters. Nature. 507(7492):381-385
Ferg, M., Armant, O., Yang, L., Dickmeis, T., Rastegar, S., and Strähle, U. (2014) Gene transcription in the zebrafish embryo: regulators and networks. Briefings in Functional Genomics. 13(2):131-43
Stegmaier, J., Shahid, M., Takamiya, M., Yang, L., Rastegar, S., Reischl, M., Strähle, U., and Mikut, R. (2014) Automated prior knowledge-based quantification of neuronal patterns in the spinal cord of zebrafish. Bioinformatics (Oxford, England). 30(5):726-33
Stegmaier, J., Otte, J.C., Kobitski, A., Bartschat, A., Garcia, A., Nienhaus, G.U., Strähle, U., Mikut, R. (2014) Fast segmentation of stained nuclei in terabyte-scale, time resolved 3D microscopy image stacks. PLoS One. 9:e90036
Tixier, V., Bataillé, L., Etard, C., Jagla, T., Weger, M., Daponte, J.P., Strähle, U., Dickmeis, T., and Jagla, K. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. USA. 110(47):18982-7
Mikut, R., Dickmeis, T., Driever, W., Geurts, P., Hamprecht, F.A., Kausler, B.X., Ledesma-Carbayo, M.J., Marée, R., Mikula, K., Pantazis, P., Ronneberger, O., Santos, A., Stotzka, R., Strähle, U., and Peyriéras, N. (2013) Automated Processing of Zebrafish Imaging Data: A Survey. Zebrafish. 10(3):401-21
Armant, O., März, M., Schmidt, R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J.C., Yang, L., Baader, I., Reischl, M., Legradi, J., Mikut, R., Stemple, D., Ijcken, W.V., van der Sloot, A., Lenhard, B., Strähle, U., and Rastegar, S. (2013) Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Developmental Biology. 380(2):351-62
Weger, M., Weger, B.D., Diotel, N., Rastegar, S., Hirota, T., Kay, S.A., Strähle, U., and Dickmeis, T. (2013) Real-time in vivo monitoring of circadian E-box enhancer activity: A robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology. 380(2):259-73
Ho, N.Y., Yang, L., Legradi, J., Armant, O., Takamiya, M., Rastegar, S., and Strähle, U. (2013) Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury. Environ. Sci. Technol.. 47(7):3316-25
Cavodeassi, F., Bene, F.D., Fürthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Strähle, U., Tiso, N., and Foulkes, N.S. (2013) Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012. Zebrafish. 10(1):119-23
Dooley, C.M., Schwarz, H., Mueller, K.P., Mongera, A., Konantz, M., Neuhauss, S.C., Nüsslein-Volhard, C., and Geisler, R. (2013) Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment cell & melanoma research. 26(2):205-217
Schmidt, R., Strähle, U., and Scholpp, S. (2013) Neurogenesis in zebrafish -- from embryo to adult. Neural Development. 8(1):3
Strähle, U., and Schmidt, R. (2012) A universal program for tissue regeneration?. Developmental Cell. 23(6):1123-1124
Zhang, J., Jeradi, S., Strähle, U., and Akimenko, M.A. (2012) Laser ablation of the sonic hedgehog-a-expressing cells during fin regeneration affects ray branching morphogenesis. Developmental Biology. 365(2):424-433
Boggetti, B., Jasik, J., Takamiya, M., Strähle, U., Reugels, A.M., and Campos-Ortega, J.A. (2012) NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Developmental Biology. 365(1):164-174
Kosmehl, T., Otte, J.C., Yang, L., Legradi, J., Bluhm, K., Zinsmeister, C., Keiter, S.H., Reifferscheid, G., Manz, W., Braunbeck, T., Strähle, U., and Hollert, H. (2012) A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments. Reproductive toxicology (Elmsford, N.Y.). 33(2):245-253
Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., and Braunbeck, T. (2012) Zebrafish embryos as an alternative to animal experiments-A commentary on the definition of the onset of protected life stages in animal welfare regulations. Reproductive toxicology (Elmsford, N.Y.). 33(2):128-132
Roostalu, U., and Strähle, U. (2012) In Vivo imaging of molecular interactions at damaged sarcolemma. Developmental Cell. 22(3):515-529
Otten, C., van der Ven, P.F., Lewrenz, I., Paul, S., Steinhagen, A., Busch-Nentwich, E., Eichhorst, J., Wiesner, B., Stemple, D., Strähle, U., Fürst, D.O., and Abdelilah-Seyfried, S. (2012) Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One. 7(2):e31041
Bloch-Zupan, A., Jamet, X., Etard, C., Laugel, V., Muller, J., Geoffroy, V., Strauss, J.P., Pelletier, V., Marion, V., Poch, O., Strahle, U., Stoetzel, C., and Dollfus, H. (2011) Homozygosity Mapping and Candidate Prioritization Identify Mutations, Missed by Whole-Exome Sequencing, in SMOC2, Causing Major Dental Developmental Defects. American journal of human genetics. 89(6):773-781
Just, S., Meder, B., Berger, I.M., Etard, C., Trano, N., Patzel, E., Hassel, D., Marquart, S., Dahme, T., Vogel, B., Fishman, M.C., Katus, H.A., Strähle, U., and Rottbauer, W. (2011) The myosin-interacting protein SMYD1 is essential for sarcomere organization. Journal of Cell Science. 124(Pt 18):3127-36
März, M., Schmidt, R., Rastegar, S., and Strähle, U. (2011) Regenerative response following stab injury in the adult zebrafish telencephalon. Developmental dynamics : an official publication of the American Association of Anatomists. 240(9):2221-2231
Busch, W., Duis, K., Fenske, M., Maack, G., Legler, J., Padilla, S., Strähle, U., Witters, H., and Scholz, S. (2011) The zebrafish embryo model in toxicology and teratology. Reproductive toxicology (Elmsford, N.Y.). 31(4):585-588
Lobbardi, R., Lambert, G., Zhao, J., Geisler, R., Kim, H.R., and Rosa, F.M. (2011) Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. Development (Cambridge, England). 138(9):1783-1794
Choi, J., Mouillesseaux, K., Wang, Z., Fiji, H.D., Kinderman, S.S., Otto, G.W., Geisler, R., Kwon, O., and Chen, J.N. (2011) Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. Development (Cambridge, England). 138(6):1173-1181
Weger, B.D., Sahinbas, M., Otto, G.W., Mracek, P., Armant, O., Dolle, D., Lahiri, K., Vallone, D., Ettwiller, L., Geisler, R., Foulkes, N.S., and Dickmeis, T. (2011) The light responsive transcriptome of the zebrafish: function and regulation. PLoS One. 6(2):e17080
Becker-Heck, A., Zohn, I.E., Okabe, N., Pollock, A., Lenhart, K.B., Sullivan-Brown, J., McSheene, J., Loges, N.T., Olbrich, H., Haeffner, K., Fliegauf, M., Horvath, J., Reinhardt, R., Nielsen, K.G., Marthin, J.K., Baktai, G., Anderson, K.V., Geisler, R., Niswander, L., Omran, H., and Burdine, R.D. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nature Genetics. 43(1):79-84
Klüver, N., Yang, L., Busch, W., Scheffler, K., Renner, P., Strähle, U., and Scholz, S. (2011) Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression. PLoS One. 6(12):e29063
März, M., Schmidt, R., Rastegar, S., and Strähle, U. (2010) Expression of the transcription factor Olig2 in proliferating cells in the adult zebrafish telencephalon. Developmental dynamics : an official publication of the American Association of Anatomists. 239(12):3336-3349
Tschopp, M., Takamiya, M., Cerveny, K.L., Gestri, G., Biehlmaier, O., Wilson, S.W., Strähle, U., and Neuhauss, S.C. (2010) Funduscopy in adult zebrafish and its application to isolate mutant strains with ocular defects. PLoS One. 5(11):e15427
Lang, M., Hadzhiev, Y., Siegel, N., Amemiya, C.T., Parada, C., Strähle, U., Becker, M.B., Muller, F., and Meyer, A. (2010) Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position. EvoDevo. 1(1):11
Strähle, U., and Grabher, C. (2010) The zebrafish embryo as a model for assessing off-target drug effects. Disease models & mechanisms. 3(11-12):689-692
Brennan, C., Dosch, R., Haramis, A.P., Luckenbacher, T., Martinez-Morales, J.R., Moro, E., Polok, B., Ramesh, T.M., Russell, C., Argenton, F., and Strähle, U. (2010) Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010. Zebrafish. 7(3):305-310
Yang, L., Rastegar, S., and Strähle, U. (2010) Regulatory interactions specifying Kolmer-Agduhr interneurons. Development (Cambridge, England). 137(16):2713-2722
Yang, L., Ho, N.Y., Muller, F., and Strahle, U. (2010) Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Toxicological sciences : an official journal of the Society of Toxicology. 115(2):379-390
Etard, C., Roostalu, U., and Strähle, U. (2010) Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos. The Journal of cell biology. 189(3):527-539
März, M., Chapouton, P., Diotel, N., Vaillant, C., Hesl, B., Takamiya, M., Lam, C.S., Kah, O., Bally-Cuif, L., and Strähle, U. (2010) Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon. Glia. 58(7):870-888
Schonthaler, H.B., Franz-Odendaal, T.A., Hodel, C., Gehring, I., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R. (2010) The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness. Mechanisms of Development. 127(3-4):203-219
Grabher, C., Patton, E.E., and Strähle, U. (2010) Sharing Chemical Libraries Within the European Zebrafish Community. Zebrafish. 7(1):83
Alshut, R., Legradi, J., Liebel, U., Yang, L., van Wezel, J., Strähle, U., Mikut, R., and Reischl, M. (2010) Methods for Automated High-Throughput Toxicity Testing Using Zebrafish Embryos. KI 2010: Advances in Artificial Intelligence. 6359:219-226
Alshut, R., Legradi, J., Mikut, R., Strähle, U., and Reischl, M. (2009) Robust Identification of Coagulated Zebrafish Eggs using Image Processing and Classification Techniques. Proceedings 19 Workshop Computational Intelligence. 50:9-21
Jacoby, A.S., Busch-Nentwich, E., Bryson-Richardson, R.J., Hall, T.E., Berger, J., Berger, S., Sonntag, C., Sachs, C., Geisler, R., Stemple, D.L., and Currie, P.D. (2009) The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment. Development (Cambridge, England). 136(19):3367-3376
Yang, L., Ho, N.Y., Alshut, R., Legradi, J., Weiss, C., Reischl, M., Mikut, R., Liebel, U., Müller, F., and Strähle, U. (2009) Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reproductive toxicology (Elmsford, N.Y.). 28(2):245-253
Lam, C.S., Maerz, M., and Strähle, U. (2009) gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain. Developmental dynamics : an official publication of the American Association of Anatomists. 238(2):475-486
Kizil, C., Otto, G.W., Geisler, R., Nüsslein-Volhard, C., and Antos, C.L. (2009) Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Developmental Biology. 325(2):329-340
Rastegar, S., Hess, I., Dickmeis, T., Nicod, J.C., Ertzer, R., Hadzhiev, Y., Thies, W.G., Scherer, G., and Strähle, U. (2008) The words of the regulatory code are arranged in a variable manner in highly conserved enhancers. Developmental Biology. 318(2):366-377
Etard, C., Roostalu, U., and Strähle, U. (2008) Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril. The Journal of cell biology. 180(6):1163-1175
Strähle, U., and Rastegar, S. (2008) Conserved non-coding sequences and transcriptional regulation. Brain research bulletin. 75(2-4):225-230
Lopes, S.S., Yang, X., Müller, J., Carney, T.J., McAdow, A.R., Rauch, G.J., Jacoby, A.S., Hurst, L.D., Delfino-Machín, M., Haffter, P., Geisler, R., Johnson, S.L., Ward, A., and Kelsh, R.N. (2008) Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics. 4(3):e1000026
Hawkins, T.A., Haramis, A.P., Etard, C., Prodromou, C., Vaughan, C.K., Ashworth, R., Ray, S., Behra, M., Holder, N., Talbot, W.S., Pearl, L.H., Strähle, U., and Wilson, S.W. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (Cambridge, England). 135(6):1147-1156
Vinothkumar, S., Rastegar, S., Takamiya, M., Ertzer, R., and Strähle, U. (2008) Sequential and cooperative action of Fgfs and Shh in the zebrafish retina. Developmental Biology. 314(1):200-214
Pézeron, G., Lambert, G., Dickmeis, T., Strähle, U., Rosa, F.M., and Mourrain, P. (2008) Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. PLoS One. 3(1):e1434
Schonthaler, H.B., Fleisch, V.C., Biehlmaier, O., Makhankov, Y., Rinner, O., Bahadori, R., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R. (2008) The zebrafish mutant lbk/vam6 resembles human multi-systemic disorders caused by aberrant trafficking of endosomal vesicles. Development (Cambridge, England). 135(2):387-399
Ferg, M., Sanges, R., Gehrig, J., Kiss, J., Bauer, M., Lovas, A., Szabo, M., Yang, L., Straehle, U., Pankratz, M.J., Olasz, F., Stupka, E., and Müller, F. (2007) The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. The EMBO journal. 26(17):3945-3956
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Strähle, U., Fischer, N., and Blader, P. (1997) Expression and regulation of a netrin homologue in the zebrafish embryo. Mechanisms of Development. 62(2):147-160
Jesuthasan, S. and Strähle, U. (1997) Dynamic microtubules and specification of the zebrafish embryonic axis. Current biology : CB. 7(1):31-42
Rauch, G.-J., Hammerschmidt, M., Blader, P., Schauerte, H.E., Strähle, U., Ingham, P.W., McMahon, A.P. and Haffter, P. (1997) WNT5 is required for tail formation in the zebrafish embryo. Cold Spring Harbor symposia on quantitative biology. 62:227-233
Strähle, U., Blader, P., and Ingham, P.W. (1996) Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos. The International journal of developmental biology. 40(5):929-940
Blader, P., Strähle, U., and Ingham, P.W. (1996) Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish, Danio rerio: developmental and evolutionary perspectives. Development genes and evolution. 206(1):3-13
Kiefer, P., Strähle, U., and Dickson, C. (1996) The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic organization. Gene. 168(2):211-215
DeVries, C.J.M., DeBoer, J., Joore, J., Strähle, U., VanAchterberg, T.A.E., Huylebröck, D., Verschüren, K., Miyazono, K., VandenEijnden-vanRaaij, A.J.M., and Zivkovic, D. (1996) Active complex formation of type I and type II activin and TGF beta receptors in vivo as studied by overexpression in zebrafish embryos. Mechanisms of Development. 54(2):225-236
Strähle, U. and Blader, P. (1994) Early neurogenesis in the zebrafish embryo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 8:692-698
Strähle, U., Blader, P., Adam, J., and Ingham, P.W. (1994) A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material. Trends in genetics : TIG. 10:75-76
Strähle, U. and Jesuthasan, S. (1993) Ultraviolet irradiation impairs epiboly in zebrafish embryos: evidence for a microtubule-dependent mechanism of epiboly. Development (Cambridge, England). 119:909-919
Strähle, U., Blader, P., Henrique, D., and Ingham, P.W. (1993) Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Genes and Development. 7:1436-1446
Strähle, U. and Ingham, P.W. (1992) Flight of fancy or a major new school?. Current biology : CB. 2:135-138