ZFIN ID: ZDB-GENE-980526-436
Gene Name: retinoid x receptor, beta a
Gene Symbol: rxrba    Nomenclature History

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Previous Names: rxrb (1), rxre (1), etID309733.19 (1), fb93c09, NR2B2-A (1), wu:fb93c09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription, DNA-templated. Predicted to localize to the RNA polymerase II transcription factor complex. Is expressed in several structures, including blastoderm; digestive system; eye; gonad; and tail bud. Orthologous to human RXRB (retinoid X receptor beta).
Genome Resources: Alliance (1),  Gene:30530 (1),  Ensembl(GRCz11):ENSDARG00000078954 (2)
GENE EXPRESSION
All Expression Data: 16 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66116]
  7 figures (7 images) from Thisse et al., 2008 [u29942]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43215 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rxrba HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rxrba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function CONTRIBUTES_TO   DNA-binding transcription factor activity, RNA polymerase II-specific (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Domain IPR021780 Nuclear/hormone receptor activator site AF-1
    Family IPR000003 Retinoid X receptor/HNF4
    Family IPR001723 Nuclear hormone receptor
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rxrba-201 (1)    Ensembl 2294
    rxrba-202 (1)    Ensembl 552
    rxrba-204 (1)    Ensembl 940
    rxrba-205 (1)    Ensembl 2548
    rxrba-206 (1)    Ensembl 780
    ncRNA rxrba-002 (1)    Ensembl 568
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rxrba No data available
    MARKER RELATIONSHIPS
    rxrba Contained in: [BAC] CH73-216M24 (1), DKEYP-84F11 (1)
    [Fosmid] CH1073-247J7 (1)
    [PAC] BUSM1-12F11 (1)
    rxrba Contains: [SNP] rs3729014 (1)
    rxrba Encodes: [EST] fb93c09, u29942 (2)
    [cDNA] MGC:66116 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131275 (1) 2508 nt
    Genomic GenBank:BX890617 182182 nt
    Select Tool
    Polypeptide UniProtKB:Q7SYN5 (1) 471 aa
    Sequence Information (all 56)
    ORTHOLOGY for rxrba ( Chr: 19 )
    CITATIONS (52)