ZFIN ID: ZDB-GENE-980526-368
Gene Name: apolipoprotein Eb
Gene Symbol: apoeb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: ApoE-2 (1), apoe, cb82 (1), hm:zeh1311, wu:fa03d06 (1), wu:fa97a11 (1), wu:fc95h12 (1), wu:fj54e06 (1), zeh1311

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have anion binding activity; identical protein binding activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including cholesterol catabolic process; lipoprotein metabolic process; and triglyceride-rich lipoprotein particle clearance. Predicted to localize to several cellular components, including high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in several structures, including digestive system; epidermis; fin bud; median fin; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
Genome Resources: Alliance (1),  Gene:30314 (1),  Ensembl(GRCz11):ENSDARG00000040295 (2)
GENE EXPRESSION
All Expression Data: 68 figures from 37 publications
Directly Submitted Expression Data: 7 figures (8 images) from Thisse et al., 2001 [cb82]
  7 figures (19 images) from Thisse et al., 2005 [eu173]
Wild-type Stages, Structures: Blastula:128-cell (2.25h-2.5h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36120 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • scu3 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-apoeb 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH apoeb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 1 Alliance {?Macular degeneration, age-related} 603075
    Alzheimer's disease 2 Alliance Alzheimer disease 2 104310
    Alzheimer's disease 3 Alliance {?Alzheimer disease, protection against, due to APOE3-Christchurch} 607822
    hyperlipoproteinemia type III Alliance Hyperlipoproteinemia, type III 617347
    {Coronary artery disease, severe, susceptibility to} 617347
    sea-blue histiocytosis Alliance Sea-blue histiocyte disease 269600
    Lipoprotein glomerulopathy 611771
    DISEASE ASSOCIATED WITH apoeb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cholesterol efflux (more)
    Cellular Component extracellular matrix (more)
    Molecular Function heparan sulfate proteoglycan binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apoeb-201 (1)    Ensembl 1521
    apoeb-204 (1)    Ensembl 846
    ncRNA apoeb-003 (1)    Ensembl 882
    apoeb-004 (1)    Ensembl 897
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM apoeb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(apoeb:LY-EGFP) apoeb EGFPLY Danio rerio 1 21
    MARKER RELATIONSHIPS
    apoeb Contained in: [BAC] DKEY-7F3 (1) (order this)
    apoeb Encodes: [EST] cb82 (1) (order this), eu173 (1), fa03d06 (1), fa97a11 (1), fc95h12 (1), fj54e06 (1), zeh1311
    [cDNA] MGC:56515 (1), MGC:77232 (1), MGC:171895 (1)
    apoeb Has Artifact: [EST] fa96d02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131098 (1) 1345 nt
    Genomic GenBank:BX004983 (1) 234489 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A8KBA6 (1) 281 aa
    Sequence Information (all 35)
    ORTHOLOGY for apoeb ( Chr: 16 )
    CITATIONS (115)