ZFIN ID: ZDB-GENE-060612-1
Gene Name: crumbs cell polarity complex component 2a
Gene Symbol: crb2a    Nomenclature History

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Previous Names: crb2 (1), oko meduzy, ome

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in several processes, including apical protein localization; embryonic retina morphogenesis in camera-type eye; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Localizes to the plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9. Is expressed in integument; nervous system; otic vesicle; and presumptive neural retina. Orthologous to human CRB2 (crumbs cell polarity complex component 2).
Genome Resources: Alliance (1),  Gene:723994 (1),  Ensembl(GRCz11):ENSDARG00000060106 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022098Tg Transgenic Insertion Unknown Unknown DNA
m98 Point Mutation Unknown Premature Stop ENU
m289 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m298 Unknown Unknown Unknown ENU
    m320 Unknown Unknown Unknown ENU
    rw267 Unknown Unknown Unknown
    rw407 Unknown Unknown Unknown
    s256 Unknown Unknown Unknown ENU
    sa12901 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18328 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32334 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-crb2a N/A 4
    MO2-crb2a N/A 3
    MO3-crb2a N/A 2
    MO4-crb2a N/A 2
    MO5-crb2a N/A 2
    DISEASE ASSOCIATED WITH crb2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 9 Alliance Focal segmental glomerulosclerosis 9 616220
    ventriculomegaly - cystic kidney disease Alliance Ventriculomegaly with cystic kidney disease 219730
    DISEASE ASSOCIATED WITH crb2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component plasma membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR001791 Laminin G domain
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crb2a-201 (1)    Ensembl 5153
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    zs-4 monoclonal IgG1 , k Mouse IHC Zebrafish International Resource Center (ZIRC)  (order this)
    14
    Ab1-crb2a polyclonal Rabbit IHC 5
    Ab2-crb Rabbit IHC 1
    Ab1-crb Rabbit IHC, WB 5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crb2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(TETRE:HA-crb2a) TETRE crb2a Danio rerio 1 3
    Tg(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    Tg1(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    Tg2(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    Tg3(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    Tg4(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    Tg5(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    Tg6(Xla.Rho:crb2a-HA) crb2aHA Danio rerioXenopus laevis 3 5
    MARKER RELATIONSHIPS
    crb2a Contained in: [Fosmid] CH1073-90E4 (1), CH1073-314H16 (1)
    crb2a Encodes: [cDNA] MGC:193515 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045299 (1) 5153 bp
    Genomic GenBank:CU855942 (1) 40595 bp
    Select Tool
    Polypeptide UniProtKB:B3DGM6 (1) 1466 aa
    Sequence Information (all 15)
    ORTHOLOGY for crb2a ( Chr: 21 )
    CITATIONS (66)