ZFIN ID: ZDB-GENE-060610-1
Gene Name: crumbs cell polarity complex component 2b
Gene Symbol: crb2b    Nomenclature History

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Previous Name: crb2l (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in several processes, including animal organ development; glomerular filtration; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Localizes to plasma membrane and protein-containing complex. Is expressed in nervous system and pronephros. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2).
Genome Resources: Alliance (1),  Gene:568520 (1),  Ensembl(GRCz11):ENSDARG00000060081 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18042 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21177 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21178 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30898 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41102 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41103 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41104 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zju201 Small Deletion Exon 2 Unknown CRISPR
    zm00452188Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-crb2b 1
    MO1-crb2b N/A 5
    MO2-crb2b N/A 2
    MO3-crb2b N/A 2
    MO4-crb2b N/A 1
    DISEASE ASSOCIATED WITH crb2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 9 Alliance Focal segmental glomerulosclerosis 9 616220
    ventriculomegaly - cystic kidney disease Alliance Ventriculomegaly with cystic kidney disease 219730
    DISEASE ASSOCIATED WITH crb2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component plasma membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-crb Rabbit IHC 1
    Ab1-crb Rabbit IHC, WB 5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crb2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(opn1mw2:shcrb2b,opn1mw2:GFP) opn1mw2 crb2bGFP Danio rerio 6 3
    Tg(opn1mw2LCR:crb2b,opn1mw2LCR:GFP) opn1mw2 crb2bGFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    crb2b Contained in: [Fosmid] ZFOS-212H11 (1), ZFOS-2658H6 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045162 (1) 5684 nt
    Genomic GenBank:CU861461 (1) 116156 nt
    Select Tool
    Polypeptide UniProtKB:Q1A5L1 (1) 1458 aa
    Sequence Information (all 18)
    ORTHOLOGY for crb2b ( Chr: 8 )
    CITATIONS (35)