ZFIN ID: ZDB-GENE-060610-1
Gene Name: crumbs cell polarity complex component 2b
Gene Symbol: crb2b    Nomenclature History

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Previous Name: crb2l (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in several processes, including animal organ development; glomerular filtration; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Localizes to the plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9. Is expressed in nervous system and pronephros. Orthologous to human CRB2 (crumbs cell polarity complex component 2).
Genome Resources: Alliance (1),  Gene:568520 (1),  Ensembl(GRCz11):ENSDARG00000060081 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18042 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21177 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21178 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30898 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41102 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41103 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41104 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zju201 Small Deletion Exon 2 Unknown CRISPR
    zm00452188Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-crb2b 1
    MO1-crb2b N/A 5
    MO2-crb2b N/A 2
    MO3-crb2b N/A 2
    MO4-crb2b N/A 1
    DISEASE ASSOCIATED WITH crb2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 9 Alliance Focal segmental glomerulosclerosis 9 616220
    Ventriculomegaly with cystic kidney disease 219730
    DISEASE ASSOCIATED WITH crb2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component plasma membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR001791 Laminin G domain
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-crb Rabbit IHC 1
    Ab1-crb Rabbit IHC, WB 5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crb2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(opn1mw2:shcrb2b,opn1mw2:GFP) opn1mw2 crb2bGFP Danio rerio 6 3
    Tg(opn1mw2LCR:crb2b,opn1mw2LCR:GFP) opn1mw2 crb2bGFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    crb2b Contained in: [Fosmid] ZFOS-212H11 (1), ZFOS-2658H6 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045162 (1) 5684 bp
    Genomic GenBank:CU861461 (1) 116156 bp
    Select Tool
    Polypeptide UniProtKB:Q1A5L1 (1) 1458 aa
    Sequence Information (all 18)
    ORTHOLOGY for crb2b ( Chr: 8 )
    CITATIONS (35)