ZFIN ID: ZDB-GENE-060610-2
Gene Name: crumbs homolog 3a
Gene Symbol: crb3a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Involved in inner ear auditory receptor cell differentiation and regulation of non-motile cilium assembly. Predicted to localize to integral component of membrane. Is expressed in brain; eye; gut; otic vesicle; and photoreceptor cell. Orthologous to human CRB3 (crumbs cell polarity complex component 3).
Genome Resources: Alliance (1),  Gene:724017 (1),  Ensembl(GRCz11):ENSDARG00000102948 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sh346 Small Deletion Unknown Unknown TALEN
sh410 Small Deletion Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-crb3a N/A 2
MO2-crb3a N/A 1
TALEN1-crb3a 1
DISEASE ASSOCIATED WITH crb3a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH crb3a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of non-motile cilium assembly (more)
Cellular Component integral component of membrane (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA crb3a-201 (1)    Ensembl 3405
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-crb Rabbit IHC 1
Ab1-crb Rabbit IHC, WB 5
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM crb3a No data available
MARKER RELATIONSHIPS
crb3a Contained in: [BAC] CH211-198P19 (1), DKEY-27E20 (1) (order this)
crb3a Encodes: [cDNA] MGC:162017 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001045322 (1) 2482 nt
Genomic GenBank:CR847534 (1) 211145 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q1A5L0 (1) 109 aa
Sequence Information (all 12)
ORTHOLOGY for crb3a ( Chr: 3 )
CITATIONS (16)