ZFIN ID: ZDB-GENE-050208-382
Gene Name: crumbs cell polarity complex component 1
Gene Symbol: crb1    Nomenclature History

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Previous Name: si:dkey-114d20.6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in cell projection morphogenesis and establishment or maintenance of epithelial cell apical/basal polarity. Localizes to protein-containing complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1).
Genome Resources: Alliance (1),  Gene:560942 (1),  Ensembl(GRCz11):ENSDARG00000100506 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
icm31 Small Deletion Exon 2 Frameshift CRISPR
la011281Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022267Tg Transgenic Insertion Unknown Unknown DNA
    sa159 Point Mutation Unknown Splice Site ENU
    sa1482 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12558 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14330 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24173 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24174 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29788 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-crb1 1
    MO1-crb1 N/A 1
    DISEASE ASSOCIATED WITH crb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Leber congenital amaurosis 8 Alliance Leber congenital amaurosis 8 613835
    pigmented paravenous chorioretinal atrophy Alliance Pigmented paravenous chorioretinal atrophy 172870
    retinitis pigmentosa 12 Alliance Retinitis pigmentosa-12 600105
    DISEASE ASSOCIATED WITH crb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process establishment or maintenance of epithelial cell apical/basal polarity (more)
    Cellular Component protein-containing complex (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crb1-202 (1)    Ensembl 4427
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-crb Rabbit IHC 1
    Ab1-crb Rabbit IHC, WB 5
    Ab3-crb1 polyclonal Rabbit IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crb1 No data available
    MARKER RELATIONSHIPS
    crb1 Contained in: [BAC] CH73-189A7 (1), CH211-195I21 (1), DKEY-114D20 (1) (order this)
    crb1 Encodes: [cDNA] MGC:195113 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044943 (1) 4427 nt
    Genomic GenBank:CR388178 (1) 171742 nt
    Select Tool
    Polypeptide UniProtKB:B3DJP2 (1) 1428 aa
    Sequence Information (all 23)
    ORTHOLOGY for crb1 ( Chr: 22 )
    CITATIONS (33)