ZFIN ID: ZDB-GENE-050208-382
Gene Name: crumbs cell polarity complex component 1
Gene Symbol: crb1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:dkey-114d20.6

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Localizes to the protein-containing complex. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 8; cone-rod dystrophy; retinitis pigmentosa; and retinitis pigmentosa 12. Is expressed in nervous system. Orthologous to human CRB1 (crumbs cell polarity complex component 1).
Genome Resources: Alliance (1),  Gene:560942 (1),  Ensembl(GRCz11):ENSDARG00000100506 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
icm31 Small Deletion Unknown Unknown CRISPR
la011281Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022267Tg Transgenic Insertion Unknown Unknown DNA
    sa159 Point Mutation Unknown Splice Site ENU
    sa1482 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12558 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14330 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24173 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24174 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29788 Point Mutation Unknown Splice Site ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-crb1 1
    MO1-crb1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH crb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Leber congenital amaurosis 8 Alliance Leber congenital amaurosis 8 613835
    pigmented paravenous chorioretinal atrophy Alliance Pigmented paravenous chorioretinal atrophy 172870
    retinitis pigmentosa 12 Alliance Retinitis pigmentosa-12 600105
    DISEASE ASSOCIATED WITH crb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process establishment or maintenance of epithelial cell apical/basal polarity (more)
    Cellular Component protein-containing complex (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR001791 Laminin G domain
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crb1-202 (1)    Ensembl 4427
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-crb Rabbit IHC 1
    Ab1-crb Rabbit IHC, WB 5
    Ab3-crb1 polyclonal Rabbit IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM crb1 No data available
    MARKER RELATIONSHIPS
    crb1 Contained in: [BAC] CH73-189A7 (1), CH211-195I21 (1), DKEY-114D20 (1) (order this)
    crb1 Encodes: [cDNA] MGC:195113 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044943 (1) 4427 bp
    Genomic GenBank:CR388178 (1) 171742 bp
    Select Tool
    Polypeptide UniProtKB:B3DJP2 (1) 1428 aa
    Sequence Clusters UniGene:17713 (1)
    Sequence Information (all 24)
    ORTHOLOGY for crb1 ( Chr: 22 )
    CITATIONS (33)