Gene

crb1

ID
ZDB-GENE-050208-382
Name
crumbs cell polarity complex component 1
Symbol
crb1 Nomenclature History
Previous Names
  • si:dkey-114d20.6
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Localizes to protein-containing complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig 3 from Desban et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With crb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leber congenital amaurosis 8 Alliance Leber congenital amaurosis 8 613835
pigmented paravenous chorioretinal atrophy Alliance Pigmented paravenous chorioretinal atrophy 172870
retinitis pigmentosa 12 Alliance Retinitis pigmentosa-12 600105
Associated With crb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Laminin G domain
UniProtKB:B3DJP2 1428
UniProtKB:A0A2R8QCM5 1410
UniProtKB:Q1L8E9 986
UniProtKB:Q1L927 1428
UniProtKB:Q1A5L3 1428
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-crb Rabbit
  • IHC
1
Ab1-crb Rabbit
  • IHC
  • WB
5
Ab3-crb1 polyclonal Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations