ZFIN ID: ZDB-GENE-051113-60
Gene Name: spectrin alpha, non-erythrocytic 1
Gene Symbol: sptan1    Nomenclature History

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Previous Names: spna2 (1), alpha2 spectrin (1), im:7157190, wu:fa20e05, wu:fb33g08, wu:fk32a10, zgc:112229

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in clustering of voltage-gated sodium channels. Localizes to node of Ranvier and paranode region of axon. Is expressed in several structures, including cranial ganglion; eye; fin; immature eye; and post-vent region. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 5. Orthologous to human SPTAN1 (spectrin alpha, non-erythrocytic 1).
Genome Resources: Alliance (1),  Gene:553383 (1),  Ensembl(GRCz11):ENSDARG00000019231 (2)
DISEASE ASSOCIATED WITH sptan1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early infantile epileptic encephalopathy 5 Alliance Epileptic encephalopathy, early infantile, 5 613477
DISEASE ASSOCIATED WITH sptan1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process clustering of voltage-gated sodium channels (more)
Cellular Component node of Ranvier (more)
Molecular Function calcium ion binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sptan1-201 (1)    Ensembl 7875
sptan1-202 (1)    Ensembl 1766
sptan1-204 (1)    Ensembl 538
ncRNA spna2-003 (1)    Ensembl 729
spna2-005 (1)    Ensembl 861
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM sptan1 No data available
MARKER RELATIONSHIPS
sptan1 Contained in: [BAC] DKEY-156G19 (1) (order this), DKEY-228B2 (1) (order this)
sptan1 Contains: [STS] chunp311, chunp313, chunp316
sptan1 Encodes: [EST] fa20e05, fb33g08, fk32a10, fq36d11 (1) (order this), IMAGE:7157190 (1), IMAGE:7163298 (1)
sptan1 Has Artifact: [cDNA] MGC:112229
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001098488 (1) 7879 nt
Genomic GenBank:CR792457 (1) 163282 nt
Select Tool
Polypeptide UniProtKB:A3FG33 (1) 2480 aa
Sequence Information (all 57)
ORTHOLOGY for sptan1 ( Chr: 21 )
CITATIONS (32)