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ZIRC
ZFIN ID: ZDB-GENE-030909-11
Gene Name: phosphoenolpyruvate carboxykinase 1 (soluble)
Gene Symbol: pck1    Nomenclature History

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Previous Names: cb856 (1), cb924 (1), fj93h11, PEPCK (1), wu:fc51c05, wu:fj93h11, zgc:63869

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Involved in ion homeostasis and response to glucose. Predicted to localize to the cytosol and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and yolk syncytial layer. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1).
Genome Resources: Alliance (1),  Gene:378727 (1),  Ensembl(GRCz11):ENSDARG00000013522 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pck1 N/A 1
DISEASE ASSOCIATED WITH pck1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Phosphoenolpyruvate carboxykinase deficiency, cytosolic 261680
DISEASE ASSOCIATED WITH pck1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to glucose (more)
Cellular Component cytosol (more)
Molecular Function GTP binding (more)
GO Terms (all 22)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pck1-201 (1)    Ensembl 2662
ncRNA pck1-002 (1)    Ensembl 708
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-pck1 monoclonal IgG2a Mouse WB Santa Cruz Biotechnology, Inc.
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pck1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(pck1:Luciferase,cryaa:mCherry) cryaapck1 LuciferasemCherry Danio rerio 1 6
Tg(pck1:Venus,cryaa:mCherry) cryaapck1 mCherryVenus Danio rerio 1 2
MARKER RELATIONSHIPS
pck1 Contained in: [Fosmid] CH1073-127N10 (1) (order this)
pck1 Encodes: [EST] cb856 (1) (order this), cb924 (1) (order this), fc51c05 (1), fj93h11
[cDNA] MGC:63869 (1) (order this)
pck1 Has Artifact: [EST] fb65b06, fb65b11
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_214751 (1) 2698 bp
Genomic GenBank:CU855794 (1) 41245 bp
Select Tool
Polypeptide UniProtKB:F1QYH3 (1) 630 aa
Sequence Clusters UniGene:37928 (1)
Sequence Information (all 19)
ORTHOLOGY for pck1 ( Chr: 6 )
CITATIONS (79)