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Gene

pck1

ID
ZDB-GENE-030909-11
Name
phosphoenolpyruvate carboxykinase 1 (soluble)
Symbol
pck1 Nomenclature History
Previous Names
  • cb856 (1)
  • cb924 (1)
  • fj93h11
  • PEPCK (1)
  • wu:fc51c05
  • wu:fj93h11
  • zgc:63869
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Acts upstream of or within ion homeostasis and response to glucose. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; midbrain; musculature system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
53 figures from 35 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Furukawa et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pck1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Phosphoenolpyruvate carboxykinase deficiency, cytosolic 261680
Associated With pck1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
Domain IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
Domain IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
Family IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
Homologous_superfamily IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
Homologous_superfamily IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
Domain Details Per Protein
Protein Length Phosphoenolpyruvate carboxykinase, C-terminal Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain Phosphoenolpyruvate carboxykinase, GTP-utilising Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal Phosphoenolpyruvate carboxykinase, N-terminal
UniProtKB:Q7T3G9 630
UniProtKB:F1QYH3 630
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pck1 monoclonal IgG2a Mouse
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations