ZFIN ID: ZDB-GENE-030909-1
Gene Name: SRY (sex determining region Y)-box 2
Gene Symbol: sox2
Sequence Ontology ID : SO:0000704

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Previous Names: soxp (1), cb236 (1), wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 121 figures from 67 publications
Directly Submitted Expression Data: 6 figures (19 images) from Thisse et al., 2001 [cb236]
  12 figures (28 images) from Rauch et al., 2003 [fb83g04]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  amacrine cell, anatomical structure, anterior macula, anterior neural plate (all 89) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents: CRISPR1-sox2 (1), MO1-sox2 (1), MO2-sox2 (1), MO3-sox2 (1), MO4-sox2 (1) (all 9) expand
PHENOTYPE
Data: 13 figures from 5 publications
Observed in: anatomical structure, caudal fin, determination of left/right asymmetry in diencephalon, ependymal cell cell proliferation (all 15) expand
DISEASE ASSOCIATED WITH sox2 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
microphthalmia Microphthalmia, syndromic 3 206900
Optic nerve hypoplasia and abnormalities of the central nervous system 206900
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of DNA binding transcription factor activity (more)
Cellular Component transcription factor complex (more)
Molecular Function CONTRIBUTES_TO DNA binding transcription factor activity (more)
GO Terms (all 18)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR022097 (1)
  • InterPro:IPR032643 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF12336 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sox2-001 (1) 2072
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-sox2 (1), Ab2-sox2 (1), Ab3-sox2 (1), Ab4-sox2 (1), Ab5-sox2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sox2
    Tg(hsp70l:sox2), tg(hsp70l:sox2-2a-nls-kikgr)
    MARKER RELATIONSHIPS
    sox2Contained in: [BAC] CH73-242D14 (1) (order this)
    sox2Encodes: [EST] cb236 (1), fb83g04 (1) (order this), fc14d07 (1)
    [cDNA] MGC:65860 (1) (order this), MGC:77389 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213118 (1) 2120bp
    Genomic GenBank:FP102167 (1) 98106bp
    Select Tool
    Polypeptide UniProtKB:Q6P0E1 (1) 315aa
    Sequence Clusters UniGene:5379 (1)
    Sequence Information (all 20)
    OTHER sox2 GENE PAGES
  • Alliance (1)
  • Gene:378723 (1)
  • VEGA:OTTDARG00000034763 (1)
  • Ensembl(GRCz10):ENSDARG00000070913 (1)
  • ORTHOLOGY for sox2 (Chr: 22)
    CITATIONS (154)