ZFIN ID: ZDB-GENE-030909-1
Gene Name: SRY (sex determining region Y)-box 2
Gene Symbol: sox2
Sequence Ontology ID : SO:0000704

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Previous Names: soxp (1), cb236 (1), wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 127 figures from 73 publications
Directly Submitted Expression Data: 12 figures (28 images) from Rauch et al., 2003 [fb83g04]
  6 figures (19 images) from Thisse et al., 2001 [cb236]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
x50 Small Deletion Unknown Frameshift, Premature Stop TALEN
Targeting reagents:
PHENOTYPE
Data: 17 figures from 7 publications
Observed in:
DISEASE ASSOCIATED WITH sox2 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
microphthalmia Microphthalmia, syndromic 3 206900
Optic nerve hypoplasia and abnormalities of the central nervous system 206900
DISEASE ASSOCIATED WITH sox2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of DNA-binding transcription factor activity (more)
Cellular Component transcription factor complex (more)
Molecular Function chromatin binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR022097 (1)
  • InterPro:IPR032643 (1)
  • InterPro:IPR036910 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF12336 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sox2-001 (1) 2072
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sox2
    MARKER RELATIONSHIPS
    sox2Contained in: [BAC] CH73-242D14 (1) (order this)
    sox2Encodes: [EST] cb236 (1), fb83g04 (1) (order this), fc14d07 (1)
    [cDNA] MGC:65860 (1) (order this), MGC:77389 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213118 (1) 2120bp
    Genomic GenBank:FP102167 (1) 98106bp
    Select Tool
    Polypeptide UniProtKB:Q6P0E1 (1) 315aa
    Sequence Clusters UniGene:5379 (1)
    Sequence Information (all 20)
    OTHER sox2 GENE PAGES
  • Alliance (1)
  • Gene:378723 (1)
  • VEGA:OTTDARG00000034763 (1)
  • Ensembl(GRCz11):ENSDARG00000070913 (2)
  • ORTHOLOGY for sox2 (Chr: 22)
    CITATIONS (176)