ZFIN ID: ZDB-GENE-030909-1
Gene Name: SRY (sex determining region Y)-box 2
Gene Symbol: sox2
Previous Names: soxp (1), cb236 (1), wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389
Location: Chr: 22   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 95 figures from 49 publications
Directly Submitted Expression Data: 6 figures (19 images) from Thisse et al., 2001 [cb236]
  12 figures (28 images) from Rauch et al., 2003 [fb83g04]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  amacrine cell, anatomical structure, anterior macula, anterior neural plate (all 80) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: CRISPR1-sox2 (1), MO1-sox2 (1), MO2-sox2 (1), MO3-sox2 (1), MO4-sox2 (1) (all 9) expand
PHENOTYPE
Data: 9 figures from 4 publications
Observed in: caudal fin, determination of left/right asymmetry in diencephalon, ependymal cell cell proliferation, eye (all 11) expand
DISEASE ASSOCIATED WITH sox2 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
microphthalmia Microphthalmia, syndromic 3 206900
Optic nerve hypoplasia and abnormalities of the central nervous system 206900
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of sequence-specific DNA binding transcription factor activity (more)
Cellular Component transcription factor complex (more)
Molecular Function chromatin binding (more)
GO Terms (all 18)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR022097 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF12336 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sox2-001 (1) 2072
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-sox2 (1), Ab2-sox2 (1), Ab3-sox2 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox2
    Tg(hsp70l:sox2)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    sox2 Contained in: [BAC] CH73-242D14 (1) (order this)
    sox2 Encodes: [EST] cb236 (1), fb83g04 (1) (order this), fc14d07 (1)
    [cDNA] MGC:65860 (1) (order this), MGC:77389 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213118 (1) 2120 bp
    Genomic GenBank:FP102167 (1) 98106 bp
    Select Tool
    Polypeptide UniProtKB:Q6P0E1 (1) 315 aa
    Sequence Clusters UniGene:5379 (1)
    Sequence Information (all 19)
    OTHER sox2 GENE PAGES
  • Gene:378723 (1)
  • VEGA:OTTDARG00000034763 (1)
  • Ensembl(Zv9):ENSDARG00000070913 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish sox2 22  
    Human SOX2 3 (3q26.3-q27)
  • OMIM:184429
  • Gene:6657
  • Mouse Sox2 3 ( 16.93 cM)
  • MGI:98364
  • Gene:20674
  • Orthology Details
    CITATIONS (118)