ZFIN ID: ZDB-GENE-030411-6
Gene Name: keratin 18a, tandem duplicate 1
Gene Symbol: krt18a.1    Nomenclature History

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Previous Names: cb83 (1), DreK18 (1), krt18, sb:cb83, wu:fa13f02, wu:fb36b04 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Predicted to localize to the intermediate filament. Human ortholog(s) of this gene implicated in liver cirrhosis. Is expressed in several structures, including EVL; cardiovascular system; gall bladder; head; and pronephric duct. Orthologous to human KRT18 (keratin 18).
Genome Resources: Alliance (1),  Gene:352912 (1),  Ensembl(GRCz11):ENSDARG00000018404 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24263 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37630 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-krt18a.1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH krt18a.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cirrhosis, cryptogenic 215600
    {Cirrhosis, noncryptogenic, susceptibility to} 215600
    DISEASE ASSOCIATED WITH krt18a.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component intermediate filament (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018039 Intermediate filament protein, conserved site
    Domain IPR039008 Intermediate filament, rod domain
    Family IPR002957 Keratin, type I
    Homologous_superfamily IPR042180 Intermediate filament, rod domain, coil 1B
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA krt18-201 (1)    Ensembl 1749
    ncRNA krt18-002 (1) 596
    krt18-003 (1) 757
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM krt18a.1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.9krt18a.1:RFP) krt18a.1 RFP Danio rerio 1 9
    Tg(-5.0krt18a.1:GAL4FF) krt18a.1 GAL4FF Danio rerio 1 2
    Tg(krt18a.1:EGFP) krt18a.1 EGFP Danio rerio 1 3
    Tg(krt18a.1:EGFP-rpl10a) krt18a.1 EGFPrpl10a Danio rerio 1 4
    Tg(krt18a.1:KALTA4-ERT2) krt18a.1 KALTA4 Danio rerio 1 5
    Tg(krt18a.1:ptmaa-RFP) krt18a.1 ptmaaRFP Danio rerio 1 4
    Tg(krt18a.1:rab5c-Venus) krt18a.1 rab5cVenus Danio rerio 1 1
    Tg(krt18a.1:shha-RFP) krt18a.1 RFPshha Danio rerio 1 3
    Tg(krt18a.1:TETAM2-2A-AmCyan) krt18a.1 2AAmCyan Danio rerio 1 4
    tg(krt18a.1:ccnb1-gfp) krt18a.1 ccnb1GFP Danio rerio 1 1
    tg(krt18a.1:gal4vp16,myl7:egfp) krt18a.1myl7 EGFPGAL4VP16 Danio rerio 1 1
    tg(krt18a.1:krt18a.1-egfp) krt18a.1 EGFPkrt18a.1 Danio rerio 1 1
    tg(krt18a.1:lifeact-mruby) krt18a.1 LIFEACTmRuby Danio rerio 1 1
    Tg(krt18a.1:LIFEACT-tdTomato) krt18a.1 LIFEACTTomato Danio rerio 1 1
    MARKER RELATIONSHIPS
    krt18a.1 Contained in: [BAC] CH211-133J6 (1)
    krt18a.1 Contains: [STS] chunp6656, chunp30032
    krt18a.1 Encodes: [EST] cb83 (1) (order this), fa13f02, fb36b04 (1)
    [cDNA] MGC:56024 (1), MGC:77698 (1), MGC:191905 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_178437 (1) 1754 nt
    Genomic GenBank:CR450756 (1) 131145 nt
    Select Tool
    Polypeptide UniProtKB:B2GQG8 (1) 431 aa
    Sequence Information (all 29)
    ORTHOLOGY for krt18a.1 ( Chr: 23 )
    CITATIONS (77)