ZFIN ID: ZDB-GENE-030411-6
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: keratin 18a, tandem duplicate 1
Gene Symbol: krt18a.1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb83 (1), DreK18 (1), krt18, sb:cb83, wu:fa13f02, wu:fb36b04 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Predicted to localize to the intermediate filament. Human ortholog(s) of this gene implicated in liver cirrhosis. Is expressed in several structures, including EVL; cardiovascular system; gall bladder; head; and pronephric duct. Orthologous to human KRT18 (keratin 18).
Genome Resources: Alliance (1),  Gene:352912 (1),  Ensembl(GRCz11):ENSDARG00000018404 (1)
GENE EXPRESSION
All Expression Data: 18 figures from 13 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2001 [cb83]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24263 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa37630 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-krt18a.1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH krt18a.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cirrhosis, cryptogenic 215600
    {Cirrhosis, noncryptogenic, susceptibility to} 215600
    DISEASE ASSOCIATED WITH krt18a.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component intermediate filament (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018039 Intermediate filament protein, conserved site
    Domain IPR039008 Intermediate filament, rod domain
    Family IPR002957 Keratin, type I
    Homologous_superfamily IPR042180 Intermediate filament, rod domain, coil 1B
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA krt18-201 (1)    Ensembl 1749
    Select Tool
    ncRNA krt18-002 (1) 596
    Select Tool
    krt18-003 (1) 757
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM krt18a.1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.9krt18a.1:RFP) krt18a.1 RFP Danio rerio 1 9
    Tg(-5.0krt18a.1:GAL4FF) krt18a.1 GAL4FF Danio rerio 1 2
    Tg(krt18a.1:EGFP) krt18a.1 EGFP Danio rerio 1 3
    Tg(krt18a.1:EGFP-rpl10a) krt18a.1 EGFP,  rpl10a Danio rerio 1 4
    Tg(krt18a.1:KALTA4-ERT2) krt18a.1 KALTA4 Danio rerio 1 5
    Tg(krt18a.1:ptmaa-RFP) krt18a.1 ptmaa,  RFP Danio rerio 1 4
    Tg(krt18a.1:rab5c-Venus) krt18a.1 rab5c,  Venus Danio rerio 1 1
    Tg(krt18a.1:shha-RFP) krt18a.1 RFP,  shha Danio rerio 1 3
    Tg(krt18a.1:TETAM2-2A-AmCyan) krt18a.1 2A,  AmCyan Danio rerio 1 4
    tg(krt18a.1:ccnb1-gfp) krt18a.1 ccnb1,  GFP Danio rerio 1 1
    tg(krt18a.1:gal4vp16,myl7:egfp) krt18a.1,  myl7 EGFP,  GAL4,  VP16 Danio rerio 1 1
    tg(krt18a.1:krt18a.1-egfp) krt18a.1 EGFP,  krt18a.1 Danio rerio 1 1
    tg(krt18a.1:lifeact-mruby) krt18a.1 LIFEACT,  mRuby Danio rerio 1 1
    Tg(krt18a.1:LIFEACT-tdTomato) krt18a.1 LIFEACT,  Tomato Danio rerio 1 1
    MARKER RELATIONSHIPS
    krt18a.1 Contained in: [BAC] CH211-133J6 (1)
    krt18a.1 Contains: [STS] chunp6656, chunp30032
    krt18a.1 Encodes: [EST] cb83 (1) (order this), fa13f02, fb36b04 (1)
    [cDNA] MGC:56024 (1), MGC:77698 (1), MGC:191905 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_178437 (1) 1754 nt
    Select Tool
    Genomic GenBank:CR450756 (1) 131145 nt
    Select Tool
    Polypeptide UniProtKB:B2GQG8 (1) 431 aa
    Select Tool
    Sequence Information (all 29)
    ORTHOLOGY for krt18a.1 ( Chr: 23 )
    CITATIONS (77)