ZFIN ID: ZDB-GENE-011213-1
Gene Name: hairy-related 9
Gene Symbol: her9    Nomenclature History

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Previous Names: Hes1a (1), wu:fc30a03 (1), zgc:100766

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in negative regulation of neurogenesis. Predicted to localize to the nucleus. Is expressed in several structures, including axis; central nervous system; neural plate; presumptive hypochord; and pronephros. Orthologous to human HES4 (hes family bHLH transcription factor 4).
Genome Resources: Alliance (1),  Gene:140613 (1),  Ensembl(GRCz11):ENSDARG00000056438 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011036Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43978 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-her9 N/A 3
    MO2-her9 N/A 2
    MO3-her9 N/A 1
    MO4-her9 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH her9 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH her9 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of neurogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003650 Orange domain
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA her9-201 (1)    Ensembl 1461
    ncRNA her9-002 (1)    Ensembl 854
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM her9 No data available
    MARKER RELATIONSHIPS
    her9 Contained in: [BAC] DKEY-27M6 (1) (order this)
    her9 Encodes: [EST] fc30a03 (1)
    [cDNA] MGC:100766 (1), MGC:174858 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131873 (1) 1448 nt
    Genomic GenBank:CR751236 (1) 108342 nt
    Select Tool
    Polypeptide UniProtKB:A7MCR9 (1) 291 aa
    Sequence Information (all 24)
    ORTHOLOGY for her9 ( Chr: 23 )
    CITATIONS (74)