Publication	Data		Fish	Anatomy
Engel-Pizcueta et al., 2024	Fig. 2		knu3Tg/knu3Tg; pfu102Tg/pfu102Tg + MO2-hes4 ,   knu3Tg/knu3Tg; pfu102Tg/pfu102Tg + CRISPR5-hes4 + CRISPR6-hes4 + CRISPR7-hes4 + CRISPR8-hes4	rhombomere neuron GFP expression increased amount, abnormal rhombomere neuron GFP expression spatial pattern, abnormal rhombomere neuronal stem cell Ab6-sox2 labeling decreased amount, abnormal rhombomere nucleus mCherry expression increased amount, abnormal rhombomere nucleus mCherry expression spatial pattern, abnormal rhombomere regulation of neurogenesis decreased process quality, abnormal
	Fig. 5		pfu103Tg/pfu103Tg + MO2-hes4	rhombomere cell division decreased rate, abnormal rhombomere compartment boundary cdkn1ca expression increased amount, abnormal rhombomere nucleus GFP expression decreased amount, abnormal
	Fig. 6		pfu103Tg/pfu103Tg + MO2-hes4	rhombomere compartment boundary GFP expression decreased amount, abnormal
	Fig. 7		pfu103Tg/pfu103Tg + MO2-hes4	rhombomere compartment boundary sox2 expression decreased amount, abnormal rhombomere lateral side sox2 expression decreased amount, abnormal rhombomere medial side sox2 expression decreased amount, abnormal rhombomere stem cell population maintenance decreased process quality, abnormal
Stenzel et al., 2022	Figure 2		hes4co66/co66	branchiostegal ray bone mineralization decreased process quality, abnormal branchiostegal ray composition, abnormal cartilage element decreased size, abnormal ceratobranchial 5 bone bone mineralization decreased process quality, abnormal ceratobranchial 5 bone composition, abnormal ceratobranchial 5 tooth biomineral tissue development decreased process quality, abnormal ceratobranchial 5 tooth composition, abnormal cleithrum bone mineralization decreased process quality, abnormal cleithrum composition, abnormal entopterygoid bone mineralization decreased process quality, abnormal entopterygoid composition, abnormal maxilla bone mineralization decreased process quality, abnormal maxilla composition, abnormal neurocranium decreased size, abnormal notochord composition, abnormal opercle bone mineralization decreased process quality, abnormal opercle composition, abnormal parasphenoid bone mineralization decreased process quality, abnormal parasphenoid composition, abnormal
	Figure 3		hes4co66/co66	neurocranium decreased size, abnormal opercle bone mineralization decreased process quality, abnormal opercle composition, abnormal parasphenoid bone mineralization decreased process quality, abnormal parasphenoid composition, abnormal
	Figure 4		hes4co66/co66; b1212Tg/b1212Tg	opercle bone mineralization decreased process quality, abnormal otolith decreased size, abnormal
	Figure 5		hes4co66/co66; b1212Tg/b1212Tg	opercle shape, abnormal
	Figure 7		hes4co66/co66	cleithrum bone mineralization decreased process quality, abnormal opercle bone mineralization decreased process quality, abnormal parasphenoid bone mineralization decreased process quality, abnormal
Coomer et al., 2020	Figure 10		hes4uky2/uky2	retina crx expression decreased amount, abnormal retina thrb expression spatial pattern, abnormal retina ventral region thrb expression decreased amount, abnormal retinal cone cell fate specification process quality, abnormal retinal outer nuclear layer nr2e3 expression decreased amount, abnormal retinal outer nuclear layer thrb expression decreased amount, abnormal whole organism thrb expression decreased amount, abnormal
	Figure 11		hes4uky2/uky2	ciliary marginal zone apoptotic process increased occurrence, abnormal retinal ganglion cell layer apoptotic process increased occurrence, abnormal retinal inner nuclear layer apoptotic process increased occurrence, abnormal retinal outer nuclear layer apoptotic process increased occurrence, abnormal
	Figure 12		hes4uky2/uky2; fl1Tg ,   hes4uky2/uky2; ucd1Tg	retinal cone cell decreased amount, abnormal retinal rod cell decreased amount, abnormal short single cone cell decreased amount, abnormal
	Figure 2		hes4uky2/uky2	cranial skeletal system development disrupted, abnormal eye decreased size, abnormal liver increased size, abnormal pericardium edematous, abnormal swim bladder aplastic, abnormal whole organism dead, abnormal whole organism decreased pigmentation, abnormal whole organism decreased size, abnormal whole organism increased curvature, abnormal whole organism viability, abnormal
	Figure 3		hes4uky2/uky2	optomotor response decreased process quality, abnormal visual system decreased functionality, abnormal visually-mediated background adaptation decreased process quality, abnormal
	Figure 4		hes4uky2/uky2; fl1Tg ,   hes4uky2/uky2	retinal rod cell decreased amount, abnormal retinal rod cell rod photoreceptor outer segment morphology, abnormal
	Figure 5		hes4uky2/uky2; ucd1Tg ,   hes4uky2/uky2	long double cone cell cone photoreceptor outer segment morphology, abnormal retinal cone cell cone photoreceptor outer segment decreased length, abnormal retinal cone cell decreased amount, abnormal short double cone cell cone photoreceptor outer segment morphology, abnormal
	Figure 7		hes4uky2/uky2; mi2001Tg	Muller cell cell body position, abnormal Muller cell decreased amount, abnormal Muller cell disorganized, abnormal Muller cell glial cell projection decreased amount, abnormal
	Figure 8		hes4uky2/uky2	retinal ganglion cell decreased amount, abnormal
	Figure 9		hes4uky2/uky2	ciliary marginal zone decreased size, abnormal
	Figure S1		hes4uky3/uky3	retinal cone cell decreased amount, abnormal
	Figure S4		hes4uky2/uky2; mi2001Tg	brain glial cell decreased amount, abnormal enteric nervous system glial cell decreased amount, abnormal