FIGURE

Figure 6.

ID

ZDB-FIG-231002-395

Publication

Brondolin et al., 2023 - Migration and differentiation of muscle stem cells are coupled by RhoA signalling during regeneration

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Figure 6.

ROCK inhibition impairs myogenesis. Gene expression in regenerating myotomes of control and Y-27632 treated larvae was examined by qPCR at 24 hpi. Myogenic genes myf5, myod and myogenin were compared, but only myod showed an upregulation in Y-27632 treated tissue (a). Cell cycle associated genes pcna, cdkn1a, ccnb1, ccnb2 and Notch activated genes her1 and her2 were downregulated in Y-27632 treated tissue, but ccnd1, ccne1, cdkn2a did not show significant differences (b). The difference in gene expression between control and Y-27632 treated tissue was tested by comparing ΔCt values using an unpaired t-test with Bonferroni correction with significance assumed where p < 0.05 (***p < 0.001, **p < 0.01, *p < 0.05, N.S. p > 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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