FIGURE

Fig. 7

ID

ZDB-FIG-220627-41

Publication

Wang et al., 2022 - α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

Other Figures

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Fig. 7

Schematic drawing of our working model. (A) Disrupting the TCA cycle alone leads to enhanced reductive carboxylation and T-ALL cell survival through TET-mediated demethylation and upregulation of IDH1 and IDH2. (B) Combined inhibition of the TCA cycle and TET-mediated demethylation kills T-ALL cells by decreasing the production of IDH1 and IDH2 and subsequently dampening reductive carboxylation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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