FIGURE

Fig. 6

ID

ZDB-FIG-220627-40

Publication

Wang et al., 2022 - α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

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Fig. 6

Combined inhibition of the TCA cycle and DNA methylation through CPI-613 and Bobcat 339 significantly decreases the tumor burden in zebrafish xenografts of human T-ALL. (A) Treatment of zebrafish xenografts with the TCA cycle inhibitor CPI-613 (2 μM) or TET1/2 inhibitor Bobcat339 (4 μM) resulted in a slightly decreased tumor burden, while combination treatment led to a significantly decreased tumor burden. (B) Quantification of the tumor fluorescence intensity in zebrafish xenografts is shown in (A). The data are presented as the mean ± s.e.m., and statistical differences are calculated using an unpaired two-tailed t-test with the vehicle as the control. Scale bar in (A) = 500 μm. * p < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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