Figure 5

Exposure of UM cells to Cdots promotes tumorigenesis by inducing ROS in both nude mouse subcutaneous and intraocular xenograft models. A) Luciferase images of tumor‐bearing mice at various time points after subcutaneous injections of pretreated UM cells. Addition of the antioxidant NAC reversed the Cdot‐induced tumorigenic effect. Cdots at 200 µg mL⁻¹ inhibited tumor growth. B) Tumors were compared at the end of the experiment. Tumor growth curves were measured starting at 1 d after inoculation (n = 5 for each group). The results were compared to those of the NC group. C) Luciferase images of tumor‐bearing mice at various time points after intraocular injection of treated mouse melanoma cells. Addition of the antioxidant NAC reversed the Cdot‐induced protumorigenesis effect. Cdots at 200 µg mL⁻¹ inhibited tumor growth. D) Comparison of tumor size at the end of the experiment. Tumor growth was monitored starting at 1 d after inoculation (n = 5 for each group). The results were compared to those of the NC group. Asterisks indicate a statistically significant difference between the control and treatment groups. n = 5, *P < 0.05.