FIGURE

Figure 3

ID

ZDB-FIG-210428-74

Publication

Ding et al., 2021 - Dose-Dependent Carbon-Dot-Induced ROS Promote Uveal Melanoma Cell Tumorigenicity via Activation of mTOR Signaling and Glutamine Metabolism

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Figure 3

Cdots promote UM cell viability, migration, and invasiveness by inducing ROS. A,B) Addition of the antioxidants Toc and NAC reversed the Cdot‐induced proviability effect in Mum2B cells. The results were compared to those of the NC group. C) Microscopy images of Mum2B cells treated with Cdots with or without antioxidants in a cell scratch migration assay. Scale bars = 100 µm. D) Quantitation of Mum2B cell migration distance from the images presented in panel (C). Addition of the antioxidants reversed the Cdot‐induced promigration effect. The results were compared to those of the NC group. E) Microscopy images of Mum2B cells treated with Cdots with or without antioxidants in a Transwell cell invasion assay. F) Quantitation of the cell invasion images shown in panel (E). The addition of antioxidants reversed the Cdot‐induced proinvasion effect. The results were compared to those of the NC group. Asterisks indicate a statistically significant difference between the control and treatment groups. n = 3, *P < 0.05. Scale bars = 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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