FIGURE

Figure 4

ID

ZDB-FIG-200406-52

Publication

Guo et al., 2020 - A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity

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Figure 4

Effect of mutant KIF1A on the miniature excitatory post-synaptic currents (mEPSCs) and miniature inhibitory post-synaptic currents (mIPSCs) of primary cultured neurons. (A) Representative trace of mEPSCs from cultured hippocampal neurons transfected with the mutant or wild-type KIF1A plasmid at a holding potential of −70 mV. (B, C) Bar graph analysis of the mEPSC frequency and amplitude (n = 8 neurons in each group, ***p < 0.001, Student's t test). (D) Representative trace of mIPSCs from cultured hippocampal neurons transfected with the mutant or wild-type KIF1A plasmids at a holding potential of −70 mV. (E, F) Bar graph analysis of the mIPSC frequency and amplitude [n = 10 in the mutant group and 8 in the wild type (WT) group, Student's t test].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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