FIGURE

Figure 3

ID

ZDB-FIG-200406-51

Publication

Guo et al., 2020 - A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity

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Figure 3

Effect of mutant KIF1A on the intrinsic excitability of primary cultured neurons. (A) Recording paradigm of passive excitability in the excitatory cultured neurons. (B) Examples of the AP responses to superimposed current steps recorded from primary cultured GFP-positive hippocampal neurons transfected with the mutant or wild-type KIF1A plasmid. (C) Resting membrane potential of the examined neurons from two groups (n = 8 neurons in each group, Student's t test). (D) Injected currents used to induce the first spikes (n = 8 neurons in each group, Student's t test). (E) Number of APs induced by the injected currents in the primary cultured GFP-positive hippocampal neurons transfected with the mutant or wild-type KIF1A plasmid (n = 8 neurons in each group, two-way ANOVA).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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