ZFIN ID: ZDB-FIG-200320-2
Chou et al., 2018 - Ribose-5-Phosphate Isomerase A Overexpression Promotes Liver Cancer Development in Transgenic Zebrafish via Activation of ERK and β-catenin Pathways. Carcinogenesis   40(3):461-473 Full text @ Carcinogenesis
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Adult

Fig. 2 RPIA-transgenic zebrafish develop steatosis, hyperplasia, dysplasia and HCC at earlier stages than control transgenic zebrafish. (A) Representative images of H&E staining from livers of controls and the two transgenic RPIA lines between 3- and 11-month-old fish. All of the magnifications were ×400. Scale bar: 50 μm. (B) Statistical analysis of H&E stain from 3 to 11 months of control fish (mCherry) and two lines of RPIA-transgenic fish (Tg1 and Tg2). N = 10 for each stage. Tg1 developed HCC as early as 9-month old, while Tg2 developed HCC as early as 7-month old.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
nn1009aTg standard conditions Adult liver dysplastic, abnormal
Adult liver fatty, abnormal
Adult liver hyperplastic, abnormal
Adult liver hepatocellular carcinoma present, abnormal
nn1009bTg standard conditions Adult liver dysplastic, abnormal
Adult liver fatty, abnormal
Adult liver hyperplastic, abnormal
Adult liver hepatocellular carcinoma present, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Carcinogenesis for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Carcinogenesis