FIGURE
Fig 5
- ID
- ZDB-FIG-200229-6
- Publication
- Concilio et al., 2020 - Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)
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Fig 5
Lentivirally transduced HeLa cells were incubated with 125I- with increasing concentration of perchlorate (ClO4-) for 50 minutes prior to two washes with cold buffer. IC50 values were determined via non-linear regression using the equation setting: {inhibitor} vs. normalized response—variable slope–inhibition in Prism 8. Human NIS ClO4- IC50 = 1.566 μM. Minke whale NIS ClO4- IC50 = 4.566 μM. Zebrafish NIS ClO4- IC50 = 0.081 μM. Values are average of triplicate assays with standard deviation. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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