ZFIN Image: Concilio et al., 2020, Fig 5

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Figure Caption

Fig 5 Perchlorate IC<sub>50</sub> determination for HA-human-, HA- minke whale-, and HA-zebrafish NIS.

Lentivirally transduced HeLa cells were incubated with ¹²⁵I^- with increasing concentration of perchlorate (ClO₄^-) for 50 minutes prior to two washes with cold buffer. IC₅₀ values were determined via non-linear regression using the equation setting: {inhibitor} vs. normalized response—variable slope–inhibition in Prism 8. Human NIS ClO₄^- IC₅₀ = 1.566 μM. Minke whale NIS ClO₄^- IC₅₀ = 4.566 μM. Zebrafish NIS ClO₄^- IC₅₀ = 0.081 μM. Values are average of triplicate assays with standard deviation.

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