FIGURE

Fig 6

ID

ZDB-FIG-200229-24

Publication

Concilio et al., 2020 - Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)

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Fig 6

Competitive substrate inhibition assays.

¹²⁵I^- uptake with competitive substrates in HeLa cells transduced with (A) HA-human NIS, (B) HA-whale NIS, or (C) HA-zebrafish NIS. Data shown as the percentage of maximum ¹²⁵I^- uptake activity (0 μM compound) maintained in the presence of increasing concentrations of substrate or inhibitor. Circular markers indicate naturally occurring anions. Triangular markers indicate anions which may occur naturally at low levels or are generated inside the organism. Square markers indicate anions not found naturally. Values are averages of duplicate assays with standard deviation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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