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Fig. 1

ID

ZDB-FIG-200212-1

Publication

Song et al., 2020 - Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

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Fig. 1

Effect of TMQ0153 on chronic myeloid leukemia cell viability.

a Chemical structure of TMQ0153. b Time- and c dose-dependent effect of TMQ0153 on K562 cell proliferation (left panel) and viability (right panel). d Inhibitory effect of increasing concentrations of TMQ0153 on the colony forming capacities of the indicated CML cell lines. Upper panel: pictures representative of three independent experiments. Lower panel: quantification of the colony numbers. a–d All data represent mean (±S.D.) of three independent experiments. e Acute toxicity assay on zebrafish embryos after 24 h of treatment with increasing concentrations of TMQ0153. Pictures are representative of 10 fishes used for each condition (left panel) and the corresponding quantification of viable embryos (right panel). Ethanol (EtOH, 70%) was used as a positive control for toxicity. f Cytotoxicity of TMQ0153 on human peripheral blood mononuclear cells (PBMCs) by Trypan blue assay after 24, 48, and 72 h of treatment (PBMC data represent the mean (±S.D.) of five independent experiments). Statistical significance was assessed as *p < 0.05, **p < 0.01, ***p < 0.001 compared to untreated cells. Two-way ANOVA (Cell viability); post hoc: Sidak’s test. One-way ANOVA (Colony formation); post hoc: Sidak’s test. Two-way ANOVA (PBMC toxicity); post hoc: Dunnett’s test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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