ZFIN ID: ZDB-FIG-180912-92
O'Hare et al., 2017 - TM6SF2 rs58542926 impacts lipid processing in liver and small intestine. Hepatology (Baltimore, Md.)   65(5):1526-1542 Full text @ Hepatology
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Term:
Stage: Day 5
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Day 5

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
ddit3 WT + MO1-dgat2 standard conditions Day 5 whole organism ISH
WT + MO1-dgat2 + MO1-tm6sf2 standard conditions Day 5 whole organism ISH
WT + MO1-tm6sf2 standard conditions Day 5 whole organism RTPCR
edem1 WT + MO1-dgat2 standard conditions Day 5 whole organism ISH
WT + MO1-dgat2 + MO1-tm6sf2 standard conditions Day 5 whole organism ISH
WT + MO1-tm6sf2 standard conditions Day 5 whole organism RTPCR
hspa5 WT + MO1-dgat2 standard conditions Day 5 whole organism ISH
WT + MO1-dgat2 + MO1-tm6sf2 standard conditions Day 5 whole organism ISH
WT + MO1-tm6sf2 standard conditions Day 5 whole organism RTPCR
xbp1 WT + MO1-dgat2 standard conditions Day 5 whole organism ISH
WT + MO1-dgat2 + MO1-tm6sf2 standard conditions Day 5 whole organism ISH
WT + MO1-tm6sf2 standard conditions Day 5 whole organism RTPCR
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-dgat2 standard conditions Day 5 liver fatty, abnormal
Day 5 liver lipid droplet increased amount, abnormal
Day 5 whole organism xbp1 expression increased amount, abnormal
Day 5 whole organism ddit3 expression increased amount, abnormal
Day 5 whole organism edem1 expression increased amount, abnormal
Day 5 whole organism hspa5 expression increased amount, abnormal
WT + MO1-dgat2 + MO1-tm6sf2 standard conditions Day 5 liver morphology, ameliorated
Day 5 liver lipid droplet amount, ameliorated
Day 5 whole organism edem1 expression amount, ameliorated
Day 5 whole organism xbp1 expression amount, ameliorated
Day 5 whole organism hspa5 expression amount, ameliorated
Day 5 whole organism ddit3 expression amount, ameliorated
WT + MO1-tm6sf2 standard conditions Day 5 liver fatty, abnormal
Day 5 liver lipid droplet increased amount, abnormal
Day 5 whole organism hspa5 expression increased amount, abnormal
Day 5 whole organism xbp1 expression increased amount, abnormal
Day 5 whole organism edem1 expression increased amount, abnormal
Day 5 whole organism ddit3 expression increased amount, abnormal
Full text @ Hepatology