ZFIN ID: ZDB-GENE-070410-90
Gene Name: DNA-damage-inducible transcript 3
Gene Symbol: ddit3    Nomenclature History

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Previous Names: CHOP (1), zgc:162630

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of lipid biosynthetic process; and response to hypoxia. Predicted to localize to several cellular components, including CHOP-ATF3 complex; CHOP-ATF4 complex; and CHOP-C/EBP complex. Is expressed in brain; caudal fin; digestive system; and head. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3).
Genome Resources: Alliance (1),  Gene:561924 (1),  Ensembl(GRCz11):ENSDARG00000059836 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20839 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ddit3 N/A 2
    MO2-ddit3 N/A 1
    PHENOTYPE
    Data: Fig. 5 from Her et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH ddit3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ddit3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to hypoxia (more)
    Cellular Component CHOP-ATF3 complex (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddit3-201 (1)    Ensembl 1388
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddit3 No data available
    MARKER RELATIONSHIPS
    ddit3 Contained in: [BAC] CH211-125M22 (1)
    ddit3 Encodes: [cDNA] MGC:162630 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001082825 (1) 1415 nt
    Genomic GenBank:BX950854 (1) 171896 nt
    Select Tool
    Polypeptide UniProtKB:F1Q964 (1) 242 aa
    Sequence Information (all 11)
    ORTHOLOGY for ddit3 ( Chr: 6 )
    CITATIONS (88)