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Gene

hspa5

ID
ZDB-GENE-031001-11
Name
heat shock protein 5
Symbol
hspa5 Nomenclature History
Previous Names
  • bip (1)
  • cb865 (1)
  • fb60h09
  • fi36d04 (1)
  • wu:fb60h09
  • wu:fi36d04 (1)
  • zgc:55994
  • zgc:77606 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Acts upstream of or within response to hypoxia and response to yeast. Located in extracellular region. Is expressed in several structures, including central nervous system; digestive system; immature eye; prechordal plate; and sensory system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
81 figures from 45 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hspa5 Human Ortholog
No data available
Associated With hspa5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018181 Heat shock protein 70, conserved site
Domain IPR042050 Endoplasmic reticulum chaperone BIP, nucleotide-binding domain
Family IPR013126 Heat shock protein 70 family
Homologous_superfamily IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Homologous_superfamily IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
Homologous_superfamily IPR043129 ATPase, nucleotide binding domain
Domain Details Per Protein
Protein Length ATPase, nucleotide binding domain Endoplasmic reticulum chaperone BIP, nucleotide-binding domain Heat shock protein 70, conserved site Heat shock protein 70 family Heat shock protein 70kD, C-terminal domain superfamily Heat shock protein 70kD, peptide-binding domain superfamily
UniProtKB:Q6P3L3 650
UniProtKB:Q7SZD3 650
Transcripts
Genome Browsers
No data available
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-hspa5 monoclonal IgG2a Mouse
  • IHC
BD Biosciences
3
Ab1-hspa5 Rabbit
  • IHC
  • WB
Sigma-Aldrich
3
Ab6-hspa5 polyclonal Rabbit
  • WB
Novus Biologicals, LLC
2
Ab10-hspa5 polyclonal IgG Rabbit
  • WB
Proteintech
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations