ZFIN ID: ZDB-GENE-031001-11
Gene Name: heat shock protein 5
Gene Symbol: hspa5    Nomenclature History

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Previous Names: bip (1), cb865 (1), fb60h09, fi36d04 (1), wu:fb60h09, wu:fi36d04 (1), zgc:55994, zgc:77606 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Involved in response to hypoxia and response to yeast. Localizes to extracellular region. Is expressed in several structures, including central nervous system; head; immature eye; prechordal plate; and sensory system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5).
Genome Resources: Alliance (1),  Gene:378848 (1),  Ensembl(GRCz11):ENSDARG00000103846 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1743Tg Transgenic Insertion 5' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33520 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hspa5
    2
    CRISPR2-hspa5
    2
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH hspa5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hspa5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to hypoxia (more)
    Cellular Component extracellular region (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-hspa5 monoclonal IgG2a Mouse IHC BD Biosciences
    3
    Ab1-hspa5 Rabbit IHC, WB Sigma-Aldrich
    3
    Ab6-hspa5 polyclonal Rabbit WB Novus Biologicals, LLC
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspa5 No data available
    MARKER RELATIONSHIPS
    hspa5 Encodes: [EST] cb865 (1) (order this), fb60h09 (1), fb80a12 (1) (order this), fi36d04
    [cDNA] MGC:55994 (1), MGC:77606 (1)
    hspa5 Has Artifact: [cDNA] MGC:110134
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213058 (1) 2356 nt
    Polypeptide UniProtKB:Q6P3L3 (1) 650 aa
    Sequence Information (all 22)
    ORTHOLOGY for hspa5 ( Chr: 5 )
    CITATIONS (130)