ZFIN ID: ZDB-GENE-990415-173
Gene Name: notch receptor 1a
Gene Symbol: notch1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: n1a (1), notch (1), deadly seven, des, wu:fc01e02, wu:fc37a05

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including animal organ development; chordate embryonic development; and regulation of cell fate specification. Predicted to localize to the integral component of membrane; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Is expressed in several structures, including digestive system; fin; mesoderm; nervous system; and tail bud. Orthologous to human NOTCH1 (notch receptor 1).
Genome Resources: Alliance (1),  Gene:30718 (1),  Ensembl(GRCz11):ENSDARG00000103554 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b420 Point Mutation Unknown Unknown
b638 Unknown Unknown Unknown ENU
bns135 Small Deletion Exon 11 Frameshift, Premature Stop TALEN
hi3263Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • notch1a_unspecified Unspecified Unknown Unknown
    p48egcq Unknown Unknown Unknown ENU
    p76emcf Unknown Unknown Unknown ENU
    sa32330 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39316 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43568 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43576 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc225 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc239c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc322b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • th35b Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tj247 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm145 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to15e Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp37 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw239 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx201 Insertion Unknown Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-notch1a
    1
    CRISPR2-notch1a
    1
    MO1-notch1a N/A 13
    MO2-notch1a N/A 1
    MO3-notch1a N/A 4
    MO4-notch1a N/A 9
    MO5-notch1a N/A 6
    MO6-notch1a N/A 1
    TALEN1-notch1a 1
    DISEASE ASSOCIATED WITH notch1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome Alliance Adams-Oliver syndrome 5 616028
    aortic valve disease 1 Alliance Aortic valve disease 1 109730
    DISEASE ASSOCIATED WITH notch1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 35)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR000800 Notch domain
    Domain IPR001881 EGF-like calcium-binding domain
    Repeat IPR002110 Ankyrin repeat
    Family IPR008297 Notch
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Domain IPR010660 Notch, NOD domain
    Domain IPR011656 Notch, NODP domain
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR020683 Ankyrin repeat-containing domain
    Family IPR022362 Neurogenic locus Notch 1
    Domain IPR024600 Domain of unknown function DUF3454, notch
    Homologous_superfamily IPR035993 Notch-like domain superfamily
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA notch1a-201 (1)    Ensembl 248
    notch1a-202 (1)    Ensembl 5848
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM notch1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(5xUAS-E1B:6xMYC-notch1a) E1BUAS notch1a Danio rerio 1 115
    Tg(hsp70l:LOXP-mCherry-STOP-LOXP-6xMYC-notch1a,emGFP) hsp70l emGFPmCherrynotch1a Danio rerio 1 3
    Tg(hsp70l:MYC-notch1a,cryaa:Cerulean) cryaahsp70l Ceruleannotch1a Danio rerio 1 3
    Tg(mitfa:NLS-Venus-2A-notch1a) mitfa 2ANLSnotch1aVenus Danio rerio 1 1
    Tg(mitfa:notch1a) mitfa notch1a Danio rerio 1 3
    Tg(Ola.Sp7:notch1a) notch1a Danio rerioOryzias latipes 1 3
    Tg(QUAS:NLS-Venus-2A-notch1a) QUAS 2ANLSnotch1aVenus Danio rerio 1 2
    MARKER RELATIONSHIPS
    notch1a Contained in: [BAC] CH73-286L20 (1), DKEY-102G19 (1) (order this)
    [Fosmid] CH1073-196N20 (1), CH1073-249F6 (1)
    notch1a Encodes: [EST] fc01e02, fc37a05
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131441 (1) 7471 bp
    Genomic GenBank:CR388125 (1) 126058 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IT11 (1) 2438 aa
    Sequence Clusters UniGene:137595 (1)
    Sequence Information (all 32)
    ORTHOLOGY for notch1a ( Chr: 21 )
    CITATIONS (313)