ZFIN ID: ZDB-GENE-990415-173
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Gene Name: notch 1a
Gene Symbol: notch1a
Sequence Ontology ID : SO:0000704

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Previous Names: n1a (1), notch (1), deadly seven, des, wu:fc01e02, wu:fc37a05

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 65 figures from 48 publications
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  adenohypophyseal placode, axis, brain, brain proliferative region (all 44) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b420 Point Mutation Unknown Unknown
b638 Unknown Unknown Unknown ENU
hi3263Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • notch1a_unspecified Unspecified Unknown Unknown
    p48egcq Unknown Unknown Unknown ENU
    p76emcf Unknown Unknown Unknown ENU
    sa32330 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa39316 Point Mutation Unknown Splice Site ENU
    sa43568 Point Mutation Unknown Premature Stop ENU
    sa43576 Point Mutation Unknown Splice Site ENU
    tc225 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tc239c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tc322b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • th35b Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tj247 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tm145 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • to15e Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tp37 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tw239 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tx201 Insertion Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • Targeting reagents: CRISPR1-notch1a (1), CRISPR2-notch1a (1), MO1-notch1a (1), MO2-notch1a (1), MO3-notch1a (1) (all 8) expand
    PHENOTYPE
    Data: 29 figures from 11 publications
    Observed in: axon guidance, choroid plexus fourth ventricle, CiD, determination of left/right asymmetry in lateral mesoderm (all 20) expand
    DISEASE ASSOCIATED WITH notch1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome Adams-Oliver syndrome 5 616028
    aortic valve stenosis Aortic valve disease 1 109730
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Notch signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 35)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR000800 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR008297 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR010660 (1)
  • InterPro:IPR011656 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR020683 (1)
  • InterPro:IPR022362 (1)
  • InterPro:IPR024600 (1)
    		•
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50258 (1)
  • PROSITE:PS50297 (1)
    		•
  • Pfam:PF00008 (1)
  • Pfam:PF00066 (1)
  • Pfam:PF06816 (1)
  • Pfam:PF07645 (1)
  • Pfam:PF07684 (1)
  • Pfam:PF11936 (1)
  • Pfam:PF12661 (1)
  • Pfam:PF12796 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA notch1a-001 (1) 5848
    Select Tool
    notch1a-002 (1) 248
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM notch1a
    Tg(5xUAS-E1b:6xMYC-notch1a), Tg(hsp70l:LOXP-mCherry-STOP-LOXP-6xMYC-notch1a,emGFP), Tg(hsp70l:MYC-notch1a,cryaa:Cerulean), tg(mitfa:nls-venus-2a-notch1a), Tg(mitfa:notch1a) (all 6) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    notch1aContained in: [BAC] CH73-286L20 (1) (order this), DKEY-102G19 (1) (order this)
    [Fosmid] CH1073-196N20 (1) (order this), CH1073-249F6 (1) (order this)
    notch1aEncodes: [EST] fc01e02, fc37a05
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131441 (1) 7471bp
    Select Tool
    Genomic GenBank:CR388125 (1) 126058bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IT11 (1) 2438aa
    Select Tool
    Sequence Clusters UniGene:137595 (1)
    Sequence Information (all 31)
    OTHER notch1a GENE PAGES
  • Gene:30718 (1)
  • VEGA:OTTDARG00000031225 (1)
  • Ensembl(GRCz10):ENSDARG00000103554 (1)
    • ORTHOLOGY for notch1a (Chr: 21)
    CITATIONS (203)