Gene

notch1a

ID
ZDB-GENE-990415-173
Name
notch receptor 1a
Symbol
notch1a Nomenclature History
Previous Names
  • n1a (1)
  • notch (1)
  • deadly seven
  • des
  • wu:fc01e02
  • wu:fc37a05
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have Notch binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and regulation of cell fate specification. Predicted to localize to integral component of membrane; nucleus; and plasma membrane. Is expressed in several structures, including digestive system; fin; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).
Genome Resources
Note
None
Expression
All Expression Data
82 figures from 61 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
44 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With notch1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Adams-Oliver syndrome Alliance Adams-Oliver syndrome 5 616028
aortic valve disease 1 Alliance Aortic valve disease 1 109730
Associated With notch1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000800 Notch domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR010660 Notch, NOD domain
Domain IPR011656 Notch, NODP domain
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR024600 Domain of unknown function DUF3454, notch
Family IPR008297 Notch
Family IPR022362 Neurogenic locus Notch 1
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR035993 Notch-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Domain of unknown function DUF3454, notch EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Neurogenic locus Notch 1 Notch Notch domain Notch-like domain superfamily Notch, NOD domain Notch, NODP domain
UniProtKB:A1A5U5 423
UniProtKB:I3IS74 21
UniProtKB:P46530 2437
UniProtKB:A0A0R4IW83 1655
UniProtKB:A0A0R4IT11 2438
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations