FIGURE

Fig. 4 S1

ID
ZDB-FIG-180208-15
Publication
Donat et al., 2018 - Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis
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Fig. 4 S1

The region of Notch activity within the endocardium is expanded in krit1ty219c mutants.

(A, B) Projections of confocal z-stack images of embryonic hearts marked by Tg(TP1:VenusPEST)s940 expression (yellow), Myh6 staining (cyan), and Actin staining (magenta) at 54 hpf. (A) In wild-type (WT), Notch activity is highest in endocardial cells of the atrioventricular canal (AVC) and outflow regions. (B) In krit1ty219c mutants, the domain of high Notch activity is expanded to ventricular and atrial endocardial cells. (C, D) Whole-mount in situ hybridization of tbx2 cardiac expression at 48 hpf. (A) Tbx2 expression is restricted to the atrioventricular canal (AVC) both in wild-type (WT) and in ccm2m201 mutants (B). Arrowheads point at the AVC. A: atrium, V: ventricle, Scale bars are 50 μm (A, B).

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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