ZFIN ID: ZDB-FIG-160713-3
Lee et al., 2016 - MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Scientific Reports   6:27284 Full text @ Sci. Rep.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage Range: Prim-5 to Day 4

Fig. 4

TALEN-mediated knockout of mcrs1 in zebrafish. (A) Homozygous mcrs1 mutant zebrafish exhibited a curved body axis at 72 hpf. (B) Measurement of the size of the eye and the brain (n>10 for each genotype; **P < 0.01, t test). (C) Disruption of retinal lamination in mcrs1 mutant zebrafish at 72 hpf. (D) Melatonin-induced aggregation of melanosome was delayed in mcrs1 mutant zebrafish. (E) Cilia in the olfactory placode were visualized by staining with anti-acetylated tubulin antibody.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mcrs1ck018/ck018 standard conditions Prim-5 olfactory placode cilium decreased length, abnormal
Protruding-mouth brain decreased size, abnormal
Protruding-mouth eye decreased size, abnormal
Protruding-mouth retina layer formation disrupted, abnormal
Day 4 brain decreased size, abnormal
Day 4 eye decreased size, abnormal
mcrs1ck018/ck018 chemical treatment: melatonin Protruding-mouth melanosome assembly delayed, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.