ZFIN ID: ZDB-FIG-160713-3
Lee et al., 2016 - MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment. Scientific Reports   6:27284 Full text @ Sci. Rep.
Observed In:
Stage Range: Prim-5 to Day 4

Fig. 4

TALEN-mediated knockout of mcrs1 in zebrafish. (A) Homozygous mcrs1 mutant zebrafish exhibited a curved body axis at 72 hpf. (B) Measurement of the size of the eye and the brain (n>10 for each genotype; **P < 0.01, t test). (C) Disruption of retinal lamination in mcrs1 mutant zebrafish at 72 hpf. (D) Melatonin-induced aggregation of melanosome was delayed in mcrs1 mutant zebrafish. (E) Cilia in the olfactory placode were visualized by staining with anti-acetylated tubulin antibody.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mcrs1ck018/ck018 standard conditions Prim-5 olfactory placode cilium decreased length, abnormal
Protruding-mouth brain decreased size, abnormal
Protruding-mouth eye decreased size, abnormal
Protruding-mouth retina layer formation disrupted, abnormal
Day 4 brain decreased size, abnormal
Day 4 eye decreased size, abnormal
mcrs1ck018/ck018 chemical treatment: melatonin Protruding-mouth melanosome assembly delayed, abnormal
ZFIN wishes to thank the journal Scientific Reports for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Sci. Rep.