FIGURE

Fig. 5

ID

ZDB-FIG-100913-26

Publication

Clifton et al., 2010 - Identification of novel inhibitors of dietary lipid absorption using zebrafish

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Fig. 5

Reduced intestinal lipid absorption in ezetimibe and compound treated zebrafish larvae.

(A–L) Lateral views of 6 day post-fertilization larvae following fixation and staining with oil red o to mark neutral lipid. (A) Unfed wild type larva. (B) Wild type larva fed 1% egg yolk. Arrows point to lipid in vasculature. (C–I) Compound treated larvae (25 μM) fed 1% egg yolk. There is reduced intestinal lipid in the compound treated larvae, with no evidence of lipid in the vasculature. Hepatic lipid accumulation is not detected. Lipid is present in the intestinal lumen of larvae treated with compound 10 and ezetimibe (50 μM; blue asterisk).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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