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Fig. 1

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ZDB-FIG-100913-22

Publication

Clifton et al., 2010 - Identification of novel inhibitors of dietary lipid absorption using zebrafish

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Fig. 1

Chemical screen identifies novel inhibitors of zebrafish lipid metabolism.

(A, B) Bright field and fluorescent images of a 6 day post-fertilization wild type zebrafish larva that had ingested the PED6 lipid reporter. Fluorescence is detected in the intestine (asterisk) and gallbladder (arrow). (C–H) Representative dose response assay shows inhibition of PED6 metabolism in larvae treated with compound 2. Inhibition of PED6 metabolism is first detected at 6.25 μM. Larvae (6 day post-fertilization) are arrayed in a 96-well plate. (I) Quantification of the effect of active compounds (25 μM) on PED6 metabolism, as determined by total gallbladder and intestinal fluorescence measured in individual larvae. Error bars – standard deviation.

Expression Data

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Antibody Labeling

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Acknowledgments

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