ZFIN Figure: Burns et al., 2009, Fig. 3

ZFIN ID: ZDB-FIG-090730-5

ZFIN ID: ZDB-FIG-090730-5

Burns et al., 2009 - A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood 113(23):5776-5782 Full text @ Blood

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	efnb2a kdrl myb vegfaa
Fish:	WT tbx16^{hi3714Tg/hi3714Tg}
Anatomical Terms:	dorsal aorta somite ventral wall of dorsal aorta hematopoietic stem cell
Stage Range:	Prim-5 to Prim-25

PHENOTYPE:

Fish:	tbx16^{hi3714Tg/hi3714Tg}
Observed In:	angiogenesis artery morphogenesis dorsal aorta hematopoietic stem cell differentiation intersegmental vessel vasculogenesis ventral wall of dorsal aorta hematopoietic stem cell
Stage Range:	Prim-5 to Prim-25

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
efnb2a	tbx16^{hi3714Tg/hi3714Tg}	standard conditions	Prim-5	Not Detected	dorsal aorta	ISH
kdrl	tbx16^{hi3714Tg/hi3714Tg}	standard conditions	Prim-5		dorsal aorta	ISH
			Prim-5	Not Detected	intersegmental vessel	ISH
myb	WT	standard conditions	Prim-25		ventral wall of dorsal aorta hematopoietic stem cell	ISH
	tbx16^{hi3714Tg/hi3714Tg}	standard conditions	Prim-25	Not Detected	ventral wall of dorsal aorta hematopoietic stem cell	ISH
vegfaa	WT	standard conditions	Prim-5		somite	ISH

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
tbx16^{hi3714Tg/hi3714Tg}	standard conditions	Prim-5	angiogenesis disrupted, abnormal
		Prim-5	artery morphogenesis disrupted, abnormal
		Prim-5	dorsal aorta morphology, abnormal
		Prim-5	intersegmental vessel aplastic, abnormal
		Prim-5	vasculogenesis disrupted, abnormal
		Prim-25	hematopoietic stem cell differentiation disrupted, abnormal
		Prim-25	ventral wall of dorsal aorta hematopoietic stem cell absent, abnormal

Full text @ Blood